Our website uses cookies. We use cookies to remember settings and to help provide you with the best experience we can. We also use cookies to continuously improve our website by compiling visitor statistics. Read more about cookies

Childhood cancer predisposition genes

The increasing use of genomic sequencing technologies in childhood cancer diagnostics provides opportunities for standardized screening of all known childhood cancer predisposition syndromes in children with cancer.
We have developed selection criteria (Table 1) for assembling a dedicated gene panel (Table 2) for germline testing of cancer predisposition in children with cancer (Byrjalsen et al Familial Cancer 2021). The panel will be updated regularly based on new developments in the field.

Suggestions for genes to be added to the panel can be sent to predict@prinsesmaximacentrum.nl




First version


Two genes added (POLE, POLD1)


One gene added (RRAS), one gene removed (PTCH2)


One gene added (AMER1)