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Childhood cancer predisposition genes

The increasing use of genomic sequencing technologies in childhood cancer diagnostics provides opportunities for standardized screening of all known childhood cancer predisposition syndromes in children with cancer.
We have developed selection criteria (Table 1) for assembling a dedicated gene panel (Table 2) for germline testing of cancer predisposition in children with cancer (Byrjalsen et al Familial Cancer 2021). The panel will be updated regularly based on new developments in the field.

Suggestions for genes to be added to the panel can be sent to predict@prinsesmaximacentrum.nl