Trials with medicinal products
BrigaPED (tumors with ALK defect) Clinical study into the safety and effectiveness of brigatinib in children and young adults with ALK+ ALCL, IMT and other solid tumors with abnormalities in the ALK gene - open for inclusion
CRISP (tumors with ALK/MET/ROS1 abnormalities) Clinical study of the safety and efficacy of the drug crizotinib in children, either alone or in combination with other drugs - open for inclusion
ESMART (different tumor types) Clinical study in children with cancer into the safety and efficacy of drugs matching a specific DNA alteration in the tumor - open for inclusion
Idasanutlin (acute leukemia/solid tumors) Clinical study of idasanutlin in combination with chemotherapy or venetoclax in children who have unresponsive or recurrent acute leukemia or solid tumors - open for inclusion
INFORM2 NivEnt (various solid tumors) Clinical study with nivolumab and entinostat in children and young adults with refractory cancer - open for inclusion
LuDO-N (neuroblastoma) Clinical study into a new radioactive drug for relapsed neuroblastoma - open for inclusion
MK-3475-051 pembrolizumab (melanoma, solid tumor, lymphoma) Clinical study with the study drug MK-3475 in children with skin cancer (melanoma), solid tumor or lymphoma - open for inclusion
Ponatinib INCB084344 (leukemia/solid tumors) Clinical study of the safety and efficacy of ponatinib for the treatment of different types of leukemia or solid tumors in children - open for inclusion
VERITAS (neuroblastoma) Clinical study evaluating two intensive treatment plans in children with high-risk neuroblastoma - closed for inclusion
Other trials
DAVINCY (all cancer types) Clinical study of extended use of the drug (fos)aprepitant to prevent chemotherapy-induced nausea and vomiting - open for inclusion
DINO (neuroblastoma) Clinical study of the effect of (immuno)therapy on immune cells (including NK cells, effector T cells and Treg cells) in patients with neuroblastoma - open for inclusion
DRUG Access protocol (solid tumors) A national protocol to facilitate access to new anti-cancer drugs and collect data from targeted anti-cancer drugs not yet eligible for reimbursement - open for inclusion
Dynamic FDG-PET Clinical study to evaluate the use of dynamic FDG-PET scan in pediatric oncology - open for inclusion
FOCUS (all cancer types) Clinical study to optimize dosing of fluconazole in children for the prevention or treatment of invasive fungal infections - open for inclusion
GAP-NBL (neuroblastoma) Clinical study of the short-term safety and tolerability of the 68Ga-SATO scan in children with or suspected neuroblastoma - open for inclusion
Metanephrines (neuroblastoma) Clinical study to evaluate the diagnostic significance of metabolites in blood compared to metabolites in urine in children with high-risk neuroblastoma - open for inclusion
PINOCCHIO (multiple types of cancer) Clinical study in children on the metabolism, distribution and excretion of chemotherapy in the body, also called pharmacokinetics - open for inclusion
Tumor donation in Childhood Cancer patients This study is designed to enable post-mortem tumor donation in children that die from all different types of pediatric solid and brain tumors, to enable research on end-stage disease - open for inclusion