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Here you will find summaries of a selection of ongoing clinical trials on neuroblastoma.

Trials with medicinal products

BrigaPED (tumors with ALK defect)  Clinical study into the safety and effectiveness of brigatinib in children and young adults with ALK+ ALCL, IMT and other solid tumors with abnormalities in the ALK gene - open for inclusion

CRISP (tumors with ALK/MET/ROS1 abnormalities)  Clinical study of the safety and efficacy of the drug crizotinib in children, either alone or in combination with other drugs - open for inclusion

ESMART (different tumor types)  Clinical study in children with cancer into the safety and efficacy of drugs matching a specific DNA alteration in the tumor - open for inclusion

INFORM2 NivEnt (various solid tumors)  Clinical study with nivolumab and entinostat in children and young adults with refractory cancer - open for inclusion

LuDO-N (neuroblastoma)  Clinical study into a new radioactive drug for relapsed neuroblastoma - open for inclusion

MK-3475-051 pembrolizumab (melanoma, solid tumor, lymphoma)  Clinical study with the study drug MK-3475 in children with skin cancer (melanoma), solid tumor or lymphoma - open for inclusion

Ponatinib INCB084344 (leukemia/solid tumors)  Clinical study of the safety and efficacy of ponatinib for the treatment of different types of leukemia or solid tumors in children - open for inclusion

VERITAS (neuroblastoma)  Clinical study evaluating two intensive treatment plans in children with high-risk neuroblastoma - closed for inclusion


Other trials

DAVINCY (all cancer types)  Clinical study of extended use of the drug (fos)aprepitant to prevent chemotherapy-induced nausea and vomiting - open for inclusion

DINO (neuroblastoma)  Clinical study of the effect of (immuno)therapy on immune cells (including NK cells, effector T cells and Treg cells) in patients with neuroblastoma - open for inclusion

DRUG Access protocol (solid tumors)  A national protocol to facilitate access to new anti-cancer drugs and collect data from targeted anti-cancer drugs not yet eligible for reimbursement - open for inclusion

Dynamic FDG-PET  Clinical study to evaluate the use of dynamic FDG-PET scan in pediatric oncology - open for inclusion

FOCUS (all cancer types)  Clinical study to optimize dosing of fluconazole in children for the prevention or treatment of invasive fungal infections - open for inclusion

GAP-NBL (neuroblastoma)  Clinical study of the short-term safety and tolerability of the 68Ga-SATO scan in children with or suspected neuroblastoma - open for inclusion

Metanephrines (neuroblastoma)  Clinical study to evaluate the diagnostic significance of metabolites in blood compared to metabolites in urine in children with high-risk neuroblastoma - open for inclusion

PINOCCHIO (multiple types of cancer)  Clinical study in children on the metabolism, distribution and excretion of chemotherapy in the body, also called pharmacokinetics - open for inclusion

Tumor donation in Childhood Cancer patients  This study is designed to enable post-mortem tumor donation in children that die from all different types of pediatric solid and brain tumors, to enable research on end-stage disease - open for inclusion