Who can enter
- Children with a newly diagnosed tumor of the bones or soft tissue, or in whom the disease has returned (recurrence)
- Children and adolescents undergoing surgery at the Princess Máxima Center for bone or soft tissue tumors
Goal
We are studying whether using ICG is helpful for all types of sarcomas in children. The fluorescent agent ICG can assist the surgeon in making the tumor visible during surgery. The goal of this study is to see how much light ICG emits in different sarcomas. After the surgery, the diseased cells that have been removed will be examined in the laboratory. We look at which parts of the tumor emit light.
Background
How much light the tumor emits when using the fluorescent agent ICG is different for each patient and tumor type. Because of this, the usefulness of ICG in helping the surgeon see the tumor may vary. We assume that ICG is influenced by the type of sarcoma, or by chemotherapy or radiation before surgery.
In this study, the diseased cells that have been removed during surgery will be examined in the laboratory. Researchers and a pathologist use a microscope to find which parts of the diseased cells have ICG. They will check if ICG is present in living or dead tumor cells. The researchers will also compare this with the amount of light ICG emitted during surgery.
The patient will not need to do anything extra for this study. The diseased cells that have been removed, will be investigated in the laboratory. Therefore, there is no extra risk or burden for the patient.