Our website uses cookies. We use cookies to remember settings and to help provide you with the best experience we can. We also use cookies to continuously improve our website by compiling visitor statistics. Read more about cookies

Elvin ’t Hart

PhD Student
Elvin ’t Hart
Elvin ’t Hart
Radio-sensitization of high-grade Glioma and diffuse intrinsic pontine glioma by focused Ultrasound-mediated drug engagement
Phone +31628024342

High-Grade Gliomas (HGG) in adults and children are highly fatal tumors. Due to the invasive nature of the disease, surgery is not always the option. Chemotherapy has low efficacy, due to the low permeability of the Blood Brain Barrier (BBB). Due to low radio-sensitivity of HGG, radiotherapy is mainly palliative. However advances in the field of microbubble mediated focused ultrasound induced BBB disruption has opened new ways to deliver chemotherapeutic agents. These chemotherapeutic agents can involve chemotherapy or radiosensitizers. The aim of the project is to investigate in animal models the potential therapeutic effect of BBB disruption due to focused ultrasound, to deliver chemotherapeutic agents at tumors in combination with radiotherapy.
  • Radiosensitisation by olaparib through focused ultrasound delivery in a diffuse midline glioma model

    • mei 2023
    • E, 't Hart, et al
    • Journal of Controlled Release
  • Towards Standardisation of a Diffuse Midline Glioma Patient-Derived Xenograft Mouse Model Based on Suspension Matrices for Preclinical Research

    • feb. 2023
    • Elvin, 't Hart, et al
    • Biomedicines
  • Blood-brain barrier permeability following conventional photon radiotherapy - A systematic review and meta-analysis of clinical and preclinical studies

    • jul. 2022
    • Elvin't, Hart, et al
    • Clinical and translational radiation oncology
  • A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

    • jul. 2020
    • Rianne, Haumann, et al
    • Journal of visualized experiments : JoVE
View all publications