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Oncogenes amplified on extrachromosomal DNA (ecDNA) are a hallmark of cancer and linked to treatment resistance and tumor heterogeneity. In my project, I use advanced imaging approaches to precisely locate and track ecDNA in cancer cells. Specifically, I examine how different ecDNA species are spatially distributed within and between cells, and how they are transcribed and functionally embedded into compartments of the cell nucleus. Our goal is to decode the unique regulatory mechanisms of ecDNA to develop new strategies that disrupt their activity in cancer.