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Caroline Lindemans

Co-PI, Pediatrician
Caroline Lindemans
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I am a pediatric immunologist and a physician scientist in the field of pediatric blood and bone marrow transplantation. We  transplant children with a range of malignant and non-malignant diseases at the pediatric  stem cell transplant ward at the Princes Maxima Center, each disease with their own challenge. Even with these therapies becoming safer over the years, there remains significant room for safer and less toxic transplant: to improve  both effectivity and decrease toxicity of these in essence curative therapies. I am leading the BMT clinical trials within the early clinical trial unit of the Maxima and  together with Stefan Nierkens we are the current  directors of the M4C Transplantation and immunotherapy.  I maintain an extensive HSCT biobank  with the UMCU adult HCT department that  allows for the biomarker and  immune cell recovery studies in  transplant patients, to related these to foavourable outcomes and the occurrence of specific complications.  My experimental GVHD research line in close collaboration with reseachers  at the Regenerative Medicine Center  of the UMC  Utrecht (Coffer&  Ped gastro lab) focuses on tissue damage as a trigger of immune responses using the human 3D intestinal organoid model.