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Céline Debou

PhD student

Studying the impact of the leukemic bone marrow niche on effector function of CAR-T cells

Céline graduated from Ghent University (Belgium) in 2023 with a Master’s degree in Biomedical sciences, specialized in oncology. Subsequently, she joined the den Boer group at the Princess Máxima Center as a PhD student in the context of the European-funded Butterfly program. 

Céline focusses on the effect of the leukemic niche on the response to CAR-T based immunotherapy in B-cell precursor acute lymphoblastic leukemia. She investigates the interplay between leukemic cells, immune cells and mesenchymal stromal cells using techniques such as spectral flow cytometry, flow sorting and live imaging. Additionally, Céline will model and manipulate the efficacy of immunotherapy in ex vivo multidimensional cultures, representing the complex interplay in the leukemic niche. Ultimately, her work is aimed to optimize CAR-T immunotherapy in order to achieve higher cure rates for children suffering from BCP-ALL.

Phone +31 88 972 50 71