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Corine Pleijte

Corine Pleijte

Molecular dissection of Ewing sarcoma related cancers

Phone 088 97 290 00

Desmoplastic Small Round Cell Tumors (DSRCTs) are members of the Ewing sarcoma group of pediatric cancers and are driven by EWSR1-WT1 gene fusion. We have successfully developed an in-vitro system for DSRCT organoids. We use the organoids to study the molecular mechanism by which the EWSR1-WT1 fusion gene product drives transformation.