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Dennis Timmerman

PhD student
Dennis Timmerman
Dennis Timmerman
Liquid biopsy microRNA-based clinical monitoring and alternative therapy of pediatric germ cell tumors (pGCTs)
Phone 088 97 25 614

Germ cell tumors (GCTs) compromise about 5% of all pediatric tumors; about 50 new cases are diagnosed within the Netherlands each year. The current clinical evaluation of pGCT patients at diagnosis (tumor extent), during treatment (tumor response) and follow-up (detection of recurrence) using standard biomarkers (serum and cerebrospinal fluid) and nuclear imaging techniques has significant limitations (sensitivity/specificity) and leads to substantial radiation exposure. Because of these limitations and possible chemotherapy resistance, some pGCT patients have poor prognosis warranting further research for better monitoring tools and alternative treatment modalities. We will investigate the value of a microRNA-based liquid biopsy assay for presence of (malignant) pGCT components, both at diagnosis and during follow-up.

  • Chromosome 3p25.3 Gain Is Associated With Cisplatin Resistance and Is an Independent Predictor of Poor Outcome in Male Malignant Germ Cell Tumors

    • apr. 2022
    • Dennis M, Timmerman, et al
    • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors

    • okt. 2021
    • Dennis M, Timmerman, et al
    • International journal of molecular sciences
  • Comparative Analyses of Liquid-Biopsy MicroRNA371a-3p Isolation Protocols for Serum and Plasma

    • aug. 2021
    • Dennis M, Timmerman, et al
    • Cancers
  • Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells-Relevance for Understanding (Germ Cell) Tumorigenesis

    • mei 2021
    • Dennis M, Timmerman, et al
    • International journal of molecular sciences
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