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High-Grade Gliomas (HGG) in adults and children are highly fatal tumors. Due to the invasive nature of the disease, surgery is not always the option. Chemotherapy has low efficacy, due to the low permeability of the Blood Brain Barrier (BBB). Due to low radio-sensitivity of HGG, radiotherapy is mainly palliative. However advances in the field of microbubble mediated focused ultrasound induced BBB disruption has opened new ways to deliver chemotherapeutic agents. These chemotherapeutic agents can involve chemotherapy or radiosensitizers. The aim of the project is to investigate in animal models the potential therapeutic effect of BBB disruption due to focused ultrasound, to deliver chemotherapeutic agents at tumors in combination with radiotherapy.