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Emma Kroeze

PhD student

The mutational spectrum of pediatric T-cell lymphoblastic lymphoma and identification of therapeutic targets

Phone 088 97 27677

T-cell lymphoblastic lymphoma (T-LBL) and T-cell acute lymphoblastic leukemia (T-ALL) are malignant counterparts of thymocytes that share common pathogenic mechanisms. T-LBL patients mostly present with mediastinal and/or nodal masses, while T-ALL patients also present with excessive blast numbers in blood and/or bone marrow compartments. It remains unknown whether T-LBL and T-ALL reflect distinct diseases or different disease states from a common malignant progenitor. This study aims to increase our understanding of pathogenic mechanisms in sporadic and predisposed T-LBL patients.

  • 18 F-FDG-PET/CT imaging in diagnostic workup of pediatric precursor B-cell lymphoblastic lymphoma

    • jan. 2023
    • Emma, Kroeze, et al
    • Pediatric blood & cancer
  • Pediatric Precursor B-Cell Lymphoblastic Malignancies

    • aug. 2022
    • , et al
    • Cancers
  • High Prevalence of Constitutional Mismatch Repair Deficiency in a Pediatric T-cell Lymphoblastic Lymphoma Cohort

    • jan. 2022
    • Emma, Kroeze, et al
    • HemaSphere
  • T-cell lymphoblastic lymphoma and leukemia: different diseases from a common premalignant progenitor?

    • jul. 2020
    • Emma, Kroeze, et al
    • Blood advances
View all publications