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Frank Holstege

Frank Holstege

Principal Investigator

Biobank & Clinical Research Committee

Prof. dr. Frank Holstege previously led a research group in the Princess Máxima Center. His research focused on transcription and (single cell) genomics in pediatric cancer. He remains affiliated as a voluntary advisor for research.

Complex structural variation is prevalent and highly pathogenic in pediatric solid tumors
- nov. 2024
- Ianthe A E M, van Belzen, et al
- Cell genomics
Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy
- feb. 2024
- Judith, Wienke, et al
- Cancer Cell
Human fetal brain self-organizes into long-term expanding organoids
- jan. 2024
- Delilah, Hendriks, et al
- Cell
Single-cell RNA sequencing of pediatric Hodgkin lymphoma to study the inhibition of T cell subtypes
- jan. 2024
- Jurrian K, de Kanter, et al
- HemaSphere
Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS
- jul. 2023
- Ianthe A E M, van Belzen, et al
- BMC Cancer

View all publications

Frank Holstege

Publications

Complex structural variation is prevalent and highly pathogenic in pediatric solid tumors

Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

Human fetal brain self-organizes into long-term expanding organoids

Single-cell RNA sequencing of pediatric Hodgkin lymphoma to study the inhibition of T cell subtypes

Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS