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  • Frank Holstege

Frank Holstege

Principal Investigator
  • Biobank & Clinical Research Committee
Prof. dr. Frank Holstege previously led a research group in the Princess Máxima Center. His research focused on transcription and (single cell) genomics in pediatric cancer. He remains affiliated as a voluntary advisor for research. 


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Publications

179 publications in total

  • Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

    • feb. 2024
    • Judith, Wienke, et al
    • Cancer Cell

  • Human fetal brain self-organizes into long-term expanding organoids

    • jan. 2024
    • Delilah, Hendriks, et al
    • Cell

  • Single-cell RNA sequencing of pediatric Hodgkin lymphoma to study the inhibition of T cell subtypes

    • jan. 2024
    • Jurrian K, de Kanter, et al
    • HemaSphere

  • Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS

    • jul. 2023
    • Ianthe A E M, van Belzen, et al
    • BMC Cancer

  • Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

    • jan. 2023
    • Jeff, DeMartino, et al
    • Nature communications
View all publications