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Ilse Timmerman

The metastatic bone marrow niche in Neuroblastoma
Phone 088 97 290 00

Cell adhesion and -communication within the context of vascular tissue and bone marrow (BM) has been my major scientific interest. In current projects, I study cell communication within the BM metastatic niche in Neuroblastoma (NB) – a childhood cancer originating from the sympathetic nervous system – as recurrences in BM are a major obstacle to cure. The microenvironment of the BM appears to possess unique protective features. BM-residing Mesenchymal Stromal Cells (MSCs), for example, have been shown to be instructed by tumor cells to support them. We therefore aim to unravel which MSCs support tumor cells in BM and how we can block the MSC-tumor dialog to sensitize metastasized tumor cells for therapy.  In close collaboration with Sanquin, we also aim to capture metastasis-related changes within BM-residing tumor cells, hematopoietic stem and progenitor cells (in the context of stem cell transplantation) and T cells (for potential development of adoptive cell therapy). Ultimately, our studies might open up new avenues for therapeutic approaches, specifically targeting metastasized tumor cells and the support they receive from the BM microenvironment.


  • G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment

    • mei 2021
    • Paula, Martinez Sanz, et al
    • Journal for ImmunoTherapy of Cancer
  • The potential of mesenchymal stromal cells in neuroblastoma therapy for delivery of anti-cancer agents and hematopoietic recovery

    • mrt. 2021
    • Caroline, Hochheuser, et al
    • Journal of Personalized Medicine
  • Mesenchymal Stromal Cells in Neuroblastoma

    • jan. 2021
    • Caroline, Hochheuser, et al
    • Stem Cells and Development
  • The metastatic bone marrow niche in neuroblastoma

    • nov. 2020
    • Caroline, Hochheuser, et al
    • Cancers
  • Peripheral Stem Cell Apheresis is Feasible Post 131Iodine-Metaiodobenzylguanidine-Therapy in High-Risk Neuroblastoma, but Results in Delayed Platelet Reconstitution

    • feb. 2019
    • Kathelijne C J M, Kraal, et al
    • Clin Cancer Res
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