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Inge van der Werf

PhD student
Inge van der Werf

Splicing Deregulation in Pediatric AML

Phone 088 97 25 186

To take a step forward in understanding the underlying biology of Pediatric Acute Myeloid Leukemia, my project focuses on alternative splicing. Alternative splicing plays a crucial role in proliferation, differentiation and development of cells and tissues, partly by expanding the coding capacity of our genome. Actually, our genome contains 20.000 genes, but we can produce more than 100.000 proteins. Leukemic cells in particular, use this process in their advantage which in turn can be exploited to improve diagnostics and prognostic tools as well as to develop new therapies.