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In the WES-KidTs project (Whole Exome Sequencing in children with Kidney Tumors), we study the impact of genetic predisposition in pediatric renal cancer, by structurally documenting phenotypic information of all patients with pediatric renal tumors, and performing whole-exome sequencing (WES) of germline DNA in patients in whom a genetic predisposition is not identified in routine targeted genetic testing. The results of this study are used to determine the frequency of known and novel renal cancer predisposing mutations, and to develop better guidelines for genetic counseling and surveillance. Ultimately, this will contribute to a better detection of genetic predisposition in children with renal cancer.