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Judith Kok

Postdoc
Judith Kok
Radiation exposure assessment and quantification in childhood cancer survivors
Phone 088 97 25 192

In about one third of the pediatric cancer patients radiotherapy is a major part of the treatment. Although essential for curing certain types of pediatric cancers, radiotherapy can also cause late health problems. Our aim is to investigate radiation exposure parameters in dose-effect (response) analyses of subsequent tumors and late health problems in childhood cancer survivors. Currently working on several research projects (upper body RT project, colon project, 3DRT project), to obtain good estimates of radiation doses to organs-at-risk (healthy tissue surrounding a tumor). For historic treatment data (mostly two dimensionally (2D) planned radiotherapy treatment) large-scale organ dose-reconstruction efforts (dosimetry) are ongoing. In modern radiotherapy (CT-based three dimensionally planned radiotherapy treatment (3DRT)), already existing dose volume data will be collected and quantified for optimal use in dose-effect (response) analyses for subsequent tumors and late health problems in childhood cancer survivors. Resulting dose metrics of these efforts will be used to further characterize risk profiles for many different late health problems.

Furthermore, I am involved as senior radiation technologist and project member in several projects on late effects after childhood cancer. Supervisor of L. Verbruggen, J. Hazewinkel-Beijer and J. Wams and students.

Supervisor(s): Cecile Ronckers, Leontien Kremer


Key Publications:

Kok JL, Teepen JC, van der Pal HJ, van Leeuwen FE, Tissing WJE, Neggers SJCMM, Loonen, JJ, Louwerens M, Versluys B, van den Heuvel-Eibrink MM, van Dulmen-den Broeder E, Jaspers MWM, van Santen HM, van der Heiden-van der Loo M, Janssens GO, Maduro JH, Bruggink AH, Jongmans MC, Kremer LCM*, Ronckers CM, DCOG-LATER Study Group. Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors Among Long-term Survivors of Childhood Cancer. JAMA Oncol. 2019 Mar 28. doi: 10.1001/jamaoncol.2018.6862 [Epub ahead of print] (*shared last authorship)

Kok JL, Teepen JC*, van Leeuwen FE, Tissing WJE, Neggers SJCMM, van der Pal HJ, Loonen JJ, Bresters D, Versluys B, van den Heuvel-Eibrink MM, van Dulmen-den Broeder E, van der Heiden-van der Loo M, Aleman BMP, Daniels LA, Haasbeek CJA, Hoeben B, Janssens GO, Maduro JH, Oldenburger F, van Rij C, Tersteeg RJHA, Hauptmann M, DCOG-LATER Study Group, Kremer LCM, Ronckers CM. Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age. Neuro Oncol. 2018 Aug 7. doi: 10.1093/neuonc/noy124. [Epub ahead of print] (*shared first authorship)

Teepen JC, Kok JL*, van Leeuwen FE, Tissing WJE, Dolsma WV, van der Pal HJ, Loonen JJ, Bresters D, Versluys B, van den Heuvel-Eibrink MM, van Dulmen-den Broeder E, van den Berg MH, van der Heiden-van der Loo M, Hauptmann M, Jongmans MC, Overbeek LI, van de Vijver MJ, Kremer LCM, Ronckers CM, DCOG-LATER Study Group. Colorectal Adenomas and Cancer After Childhood Cancer Treatment: A DCOG-LATER Record Linkage Study. J Natl Cancer Inst. 2018 Jul 1;110(7):758-767 (*shared first authorship)

Teepen JC, Kok JL, Kremer LCM, Tissing WJE, van den Heuvel-Eibrink MM, Loonen JJ, Bresters D, van der Pal HJ, Versluys B, van Dulmen-den Broeder E, Nijsten T, Hauptmann M, Hollema N, Dolsma WV, van Leeuwen FE, Ronckers CM, DCOG-LATER Study Group. Long-Term Risk of Skin Cancer Among Childhood Cancer Survivors: A DCOG-LATER Cohort Study. J Natl Cancer Inst. 2019 Feb 25. doi: 10.1093/jnci/djy212. [Epub ahead of print]