I will be working on childhood Hodgkin’s lymphoma. We want to optimize and expand the FACS protocol that has been set up by the Holstege group to sort tumor cells and separate them from the microenvironment. This will allow us to perform whole genome sequencing on pure tumor cells to characterize the genetic aberrations, and single-cell RNA-sequencing to study the interactions between the tumor cells and its microenvironment, adding new insight into the extensive immune cell presence in this tumor. Furthermore, I will collaborate with Axel Rosendahl Huber and Eline Bertrums and assist in their project that investigates the genetic aberrations and signatures in second cancers.
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