Our website uses cookies. We use cookies to remember settings and to help provide you with the best experience we can. We also use cookies to continuously improve our website by compiling visitor statistics. Read more about cookies

Leendert Looijenga

Principal Investigator
Leendert Looijenga
Leendert Looijenga
Leendert joined the Princess Máxima Center in the fall of 2018. His research group focuses on translational patho-oncology.
Investigation of the pathogenesis of the various types of human germ cell tumors with the goal to perform optimal (early) diagnosis and treatment, including identification and application of (molecular) biomarkers. This will result in the most effective treatment with limited side effects, both on the short and long term.

 

Phone +31 (0) 88 972 52 11


Leendert Looijenga studied biology at the University of Groningen and graduated (cum laude) with a specialization in medical cell biology (1989). After being a visiting scientist (Anthropogenetics, Leiden University), he started the Laboratory for Experimental Patho-Oncology at the Daniel den Hoed Cancer Center (Rotterdam). In 1994, he defended his thesis, "Pathobiology of germ cell tumors of the adult testis: views and news" (Erasmus University Rotterdam), and became initiating scientist and staff member. In 1998, the laboratory moved to the Josephine Nefkens Institute, Department of Pathology. In 2005 he became Professor of Translational Patho-Oncology at the Erasmus MC. Looijenga is leading an active group of clinicians and scientists (in training), related to understanding the processes involved in normal and aberrant gonadal development. This has significant impact on prediction of the individual risk to develop a (malignant) germ cell tumor in time as well as potential for (future) fertility. Identification and application of clinically relevant diagnostic, prognostic and predictive markers is one of the targets. These are applied both on tissues as well as liquid biopsies (serum/plasma/semen). The targets focused on are development of tools for early diagnosis as well as prediction of clinical behavior of the tumor, including systemic treatment sensitivity.

  • Chromosome 3p25.3 Gain Is Associated With Cisplatin Resistance and Is an Independent Predictor of Poor Outcome in Male Malignant Germ Cell Tumors

    • apr. 2022
    • Dennis M, Timmerman, et al
    • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • Differential methylation EPIC analysis discloses cisplatin-resistance related hypermethylation and tumor-specific heterogeneity within matched primary and metastatic testicular germ cell tumor patient tissue samples

    • dec. 2021
    • João, Lobo, et al
    • Clinical Epigenetics
  • Combining hypermethylated rassf1a detection using ddpcr with mir-371a-3p testing

    • okt. 2021
    • João, Lobo, et al
    • Cancers
  • Circulating MicroRNAs, the Next-Generation Serum Biomarkers in Testicular Germ Cell Tumours

    • okt. 2021
    • Ricardo, Leão, et al
    • European Urology
  • Comparative Analyses of Liquid-Biopsy MicroRNA371a-3p Isolation Protocols for Serum and Plasma

    • aug. 2021
    • Dennis M, Timmerman, et al
    • Cancers
View all publications