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Li Yang

Li Yang

PhD student
Fusion proteins for regeneration after treatment-induced damage

 

I obtained my bachelor’s degree in clinical medicine (M.B.B.S.) and master’s degree in oncology (M.Med.). During my postgraduate study at the National Natural Science Foundation of China in the Oncology Laboratory, I mainly studied the tumor microenvironment and the immune escape mechanisms of liver cancer.

In November 2023, I started my PhD project at the Janda group. I am engineering different Wnt-cytokine fusion proteins, which combine antibody-based Wnt-surrogates with cytokines. We aim to activate both signaling pathways with these fusion proteins to promote damage repair in the intestine by stimulating the dedifferentiation of mature cells back to regenerate cells. If the Wnt-cytokine fusion protein with the optimal activity is determined, we will validate its activity in intestinal organoids after radiation. With this innovative protein engineering research, I aim to develop a fusion protein that promotes regeneration after treatment-induced damage and characterize this new axis of regenerative medicine.

  • NLRP6 TARGETING SUPPRESSES COLONIC TUMORIGENESIS VIA P53-DEPENDENT AND INDEPENDENT CELLULAR SENESCENCE

    • jan. 2019
    • Zengfu, Xue, et al
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