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Luca Wams

Luca Wams

Research assistant

Health problems after 3D-planned pediatric radiotherapy: A nation-wide cohort study

In about one third of the pediatric cancer patients radiotherapy is a major part of the treatment. Although essential for curing certain types of pediatric cancers, radiotherapy can also cause late health problems. From the late 90s onwards, the radiotherapy treatment switched from two dimensionally planned radiotherapy (2DRT) treatment to CT-based three dimensionally planned radiotherapy (3DRT) treatment. In 3DRT, the dose to the healthy surrounding tissue is expected to be lower, although a larger volume of healthy tissue receives this lower dose. The lower dose to surrounding tissue in 3DRT will hypothetically lead to a reduction in late health problems, but clinical data about this reduction in large cohorts is scarce yet. (Links to more info on this study, or other research on late effects of radiation exposure)

As research assistant, my main role in this study is to calculate the doses that were delivered to surrounding tissue after 3DRT treatment, by delineating organs at risk (OARs) in the collected treatment plans from pediatric cancer patients in this cohort. My main tasks involve delineation and calculating Dose Volume Histograms (DVHs), to make the collected information available for analysis goals.

Supervisor(s): Josien Hazewinkel-Beijer, Judith Kok, Jop Teepen