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Margit Bleijs

PhD Student
Margit Bleijs

Molecular dissection of Ewing sarcoma related cancers

Phone -
Email M.W.Bleijs-2@prinsesmaximacentrum.nl

 

Desmoplastic Small Round Cell Tumors (DSRCTs) are members of the Ewing sarcoma group of pediatric cancers and are driven by EWSR1-WT1 gene fusion. We have successfully developed an in-vitro system for DSRCT organoids.  We use the organoids to study the molecular mechanism by which the EWSR1-WT1 fusion gene product drives transformation.