The number of long-term survivors of childhood cancer increases as a result of improvements in cancer therapies. Long-term follow-up care for childhood cancer survivors is important to facilitate early detection of health problems and timely initiation of interventions to preserve health. There is a need to develop appropriate recommendations that will ensure that childhood cancer survivors receive the best patient care. The International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) endeavors to develop international guidelines for the long-term follow-up of these survivors. We do this by conducting systematic literature reviews, development of evidence summaries, evaluation of the evidence according to methods set up by the Cochrane Childhood Cancer, and the formulation of recommendations for each guideline topic to facilitate early detection of health problems and in turn, promote quality of life for these survivors.