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Olaf Heidenreich

Group leader
Olaf joined the Princess Máxima Center in 2018 and leads a research team that focuses on the role of fusion genes in leukemia.

Olaf Heidenreich received a PhD degree from the University of Göttingen. During this time he worked on catalytic RNAs with Fritz Eckstein at the Max Planck Institute for Experimental Medicine. After a postdoc at the Scripps Research Institute in La Jolla, California, he was e a senior research associate at the Medical School Hannover and a lecturer at the University of Tübingen. In 2007, he joined the Northern Institute for Cancer Research at Newcastle University as a Senior Lecturer and became a Professor of Molecular Haematology in 2012. In 2018, he joined the Princess Máxima Center as senior PI.  His research interests focus on leukaemic fusion genes, their impact on malignant self-renewal and their exploitation as cancer-specific therapeutic targets.

  • Fusion gene depletion eliminates stemness and induces bidirectional differentiation of acute myeloid leukemia

    • jan. 2025
    • Polina K., Derevianko, et al
    • Blood
  • Combining CRISPR-Cas9 and TCR exchange to generate a safe and efficient cord blood-derived T cell product for pediatric relapsed AML

    • apr. 2024
    • Vania Lo, Presti, et al
    • Journal for ImmunoTherapy of Cancer
  • Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1

    • mrt. 2024
    • Annelisa M., Cornel, et al
    • Journal for ImmunoTherapy of Cancer
  • Acute myeloid leukemias with UBTF tandem duplications are sensitive to Menin inhibitors

    • feb. 2024
    • Juan M., Barajas, et al
    • Blood
  • Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

    • dec. 2023
    • Daniel J L, Coleman, et al
    • Cell reports
View all publications