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Sjors Middelkamp

Postdoc
Sjors Middelkamp
Tracing somatic DNA variants in cancer and healthy cells

All cells in the body acquire DNA changes (mutations) during life. Many of these mutations are only present in specific subpopulations of cells, depending on the timing and the tissue in which they arose. Some of these DNA mutations can contribute to the development of cancer. We use new technologies to detect these mutations in small groups of cells derived from patients. This allows us to determine the origin of cancer-related mutations during development and how these mutations can lead to cancer