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Tiago Carvalheiro

Postdoc
Tiago Carvalheiro
Tiago Carvalheiro
Monitor the immune microenvironment and systemic immune effects in pediatric brain tumors

Survival amongst children with high-grade central nervous system (CNS) tumors is dismal. New treatment modalities are needed to increase survival and diminish morbidity. Immune therapies like CAR-T therapy, checkpoint inhibition and oncolytic viruses are new and promising options that need to be explored for these patients. In order to implement smart intervention trials for immune therapy, characterization of the immune system response in children with CNS tumors is crucial, since currently this information is hardly available.

Therefor, we aim to quantify and characterize the tumor immune microenvironment and to study the influence of the tumor on immune parameters in different compartments (eg. blood). We also set out to evaluate the effect of therapy on the immune profiles. This will give the opportunity to design tailored trials with immune therapy in the future and may give insight in prognostic markers for the different tumor entities.

  • Reduced numbers of regulatory T cells in chronic heart failure seems not to be restored by cardiac resynchronization therapy

    • feb. 2023
    • Sílvia, Martins, et al
    • BMC cardiovascular disorders
  • Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis

    • jan. 2023
    • Nila H, Servaas, et al
    • Arthritis & rheumatology (Hoboken, N.J.)
  • Central Role of Semaphorin 3B in a Serum-Induced Arthritis Model and Reduced Levels in Patients With Rheumatoid Arthritis

    • jun. 2022
    • Ana, Igea, et al
    • Arthritis & rheumatology (Hoboken, N.J.)
  • Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α

    • mei 2022
    • Andrea, Ottria, et al
    • Rheumatology (Oxford, England)
  • CXCL4 drives fibrosis by promoting several key cellular and molecular processes

    • jan. 2022
    • Alsya J, Affandi, et al
    • Cell reports
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