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Yvette Matser

MD-PhD student
Catecholamines and Metabolism – application for neuroblastoma diagnostics, risk assessment and identification of potential new therapeutic targets
Phone 06 22 33 35 80

Co-PI dr. André van Kuilenburg, laboratory Genetic Metabolic Disease, AMC

Neuroblastoma tumor cells excrete catecholamine metabolites that can be detected in urine. These metabolites are used to diagnose neuroblastoma and to monitor disease activity during therapy. Our studies focus on finding the most optimal use for urinary catecholamines in the diagnostic process together with other diagnostic tools. We further study how urinary catecholamine metabolites relate to disease outcomes and want to find better ways stratify patients into risk groups. Moreover, by analyzing urinary excretion patterns and comparing this with molecular data and genetic profiles, we aim to deepen our understanding of tumor biology that hopefully leads to finding more treatment targets. Taken together, our projects are translational in nature and aim to bring laboratory data to the clinic, thereby improving diagnosis, therapy and prognosis of neuroblastoma.

  • Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

    • feb. 2024
    • Judith, Wienke, et al
    • Cancer Cell
  • Optimising urinary catecholamine metabolite diagnostics for neuroblastoma

    • jun. 2023
    • Yvette A.H., Matser, et al
    • Pediatric Blood and Cancer
  • Mutational spectrum of ATRX aberrations in neuroblastoma and associated patient and tumor characteristics

    • jun. 2022
    • Michael R., van Gerven, et al
    • Cancer Science
  • Urinary 3-Methoxytyramine Is a Biomarker for MYC Activity in Patients With Neuroblastoma

    • jan. 2022
    • Yvette, Matser, et al
    • JCO precision oncology
  • Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients

    • jul. 2018
    • Yvette A.H., Matser, et al
    • American Journal of Transplantation
View all publications