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Gehonoreerde biobank verzoeken

Het overzicht van verzoeken voor de biobank die door de Biobank en Data Access Commissie en door de CRC zijn goedgekeurd vindt u hieronder.
Project number Project title  PI Date of approval
PMCLAB2018.000 The Máxima Genome Program Prof.dr. Holstege/ Dr. Tops
/ Dr. Kemmeren
16-Apr-18
PMCLAB2018.001 Dexa-dagen 2 studie (SKION OC 2017-022) Prof.dr. van den Heuvel-Eibrink 14-Nov-17
PMCLAB2018.002 MTX-FO studie (SKION OC 2018-006) Prof.dr. van den Heuvel-Eibrink 13-Mar-18
PMCLAB2018.004 Development of in vitro and in vivo research models for pediatric brain tumors Dr. Hulleman 2-Jul-18
PMCLAB2018.005 Generation of organoid models from patient-derived renal and rhabdoid tumors for the development of novel therapies Dr. Drost 19-Jul-18
PMCLAB2018.006 Generation of organoid models from patient-derived renal tumors for the development of novel therapies Dr. Drost 19-Jul-18
PMCLAB2018.007 Tracking the clonal origin of childhood acute myeloid leukemia Dr. van Boxtel 19-Jul-18
PMCLAB2018.008  Identification of translocation-specific gene expression, alternative splicing and non-coding RNA signatures in high-risk pediatric leukemias Dr. Stam 19-Jul-18
PMCLAB2018.009 Pediatric sarcoma tumoroid and single cell RNAseq analyses Prof.dr. Holstege/Dr. van de Wetering/ Dr. Janda 19-Jul-18
PMCLAB2018.010 Identification of novel drugs and drug targets for the treatment of patients harboring NUP98 gene rearrangements, a poor prognostic patient group in pediatric acute myeloid leukemia. Dr. Stam 19-Jul-18
PMCLAB2018.011 WES-KidTs (Whole Exome Sequencing in children with Kidney Tumors) Prof.dr. van den Heuvel-Eibrink 19-Jul-18
PMCLAB2018.013 Multi-platform analysis of TSC Subependymal Giant Cell Astrocytoma (SEGA) to identify novel therapeutic approaches Dr. Aronica 19-Jul-18
PMCLAB2018.014 Clinical aspects of neural crest development and anti-GD2 biomarker study for visualization and prognostification in neuroblastoma patients. Prof.dr. van Noesel 19-Jul-18
PMCLAB2018.015 Liquid-biopsy based tumor detection for rhabdomyosarcoma to improve risk stratification at diagnosis and to improve response evaluation upon treatment Dr. Tytgat 19-Jul-18
PMCLAB2018.016 Detection of cooperative and mutually exclusive genetic alterations in pediatric cancer Dr. Kemmeren 19-Jul-18
PMCLAB2018.017 SV detection/Improving detection of structural variation in pediatric cancer Dr. Kemmeren 4-Oct-18
PMCLAB2018.018 FLOWSOM analysis of AML flow cytometric data Dr. Phillipé/Dr. de Haas 4-Oct-18
PMCLAB2018.019 A comparison of new genomic technologies for detecting small structural variants Prof.dr. Holstege 28-Jan-19
PMCLAB2018.020 Cancer Immunotherapy (CIT) Cohort Dr. Dierselhuis 28-Jan-19
PMCLAB2018.021 The role of connective tissue growth factor (CTGF) as biomarker for Pediatric bone marrow failure. Dr. Leguijt 6-Dec-18
PMCLAB2018.022 Somatic mutational footprints in tumors caused by DNA repair syndromes and congenital immunodeficiency syndromes Dr. Kuiper 6-Dec-18
PMCLAB2019.024 Development of a cord blood stem cell-derived anti-AML dendritic cell vaccine: Towards powerful "anti-AML immunity" after cord blood transplantation Dr. Plantinga/Dr. Nierkens 31-Jan-19
PMCLAB2019.025 Breaking steroid resistance for T-ALL: phospho-proteomics and inhibitor testing Dr. Meijerink 18-Jul-19
PMCLAB2019.026 Mutational effects of chemotherapy on normal cells of childhood cancer survivors Dr. van Boxtel 31-Jan-19
PMCLAB2019.027 Tracing the causes and consequences of DNA damage in single hematopoietic stem cells of human Fanconi anemia patients Dr. Belderbos 31-Jan-19
PMCLAB2019.028 Unraveling pediatric AML without a known driver Dr. Noort 31-Jan-19
PMCLAB2019.029 Mechanisms of HOX-mediated Leukemogenesis in AML Dr. Adriaanse 4-Feb-19
PMCLAB2019.030 Molecular characterization of pediatric germ cell tumors: towards clinical application Dr. Looijenga 9-May-19
PMCLAB2019.031 Population dynamics of blood in Down syndrome-associated leukemia patients Dr. van Boxtel 28-Feb-19
PMCLAB2019.032 Precusor B-cell acute lymphoblastic leukaemia with Ig-MYC translocation Prof.dr. Vormoor 21-Feb-19
PMCLAB2019.033 Clonal heterogeneity and therapy resistance in Burkitt lymphoma Dr.Loeffen/ Dr. Beishuizen 21-Feb-19
PMCLAB2019.034 Mapping CLOnal evolution by Next-generation sequencing in multi-relapsed Acute Lymphoblastic B-cell precursor leukemia (CLONAL-B) Dr. Westera/Dr. de Haas 28-Feb-19
PMCLAB2019.035 Single cell analysis of pediatric medulloblastomas Prof.dr. Stunnenberg 28-Feb-19
PMCLAB2019.036 Arterial and venous thrombosis in children, teenagers and young adults treated for acute lymphoblastic leukemia/lymphoma: a joint Ponte di Legno Toxicity Working Group/ iBFM study Dr. van der Sluis 28-Feb-19
PMCLAB2019.037 A living neuroblastoma biobank with full molecular characterization Dr. Molenaar 14-Mar-19
PMCLAB2019.038 The clinical and molecular genetic spectrum of immature T- and B-cell malignancies Dr. Kroeze 14-Mar-19
PMCLAB2019.039 Bachelor thesis on effectivity of the ALL-10 treatment protocol; Research question: What is the influence of genetic abnormalities on different parameters, e.g. MRD and prednisone response in patients with T-cell acute lymphoblastic leukemia, treated by the ALL-10-protocol? Dr. van den Berg 11-Apr-19
PMCLAB2019.040 Drug resistance profiling of children with ALL Prof.dr. den Boer 11-Apr-19
PMCLAB2019.041 Digital image analysis by deep learning of Wilms tumors Dr. de Krijger 11-Apr-19
PMCLAB2019.042 Use of quality indicators in neuroblastoma treatment: a feasibility assessment Dr. Dijkstra 25-Apr-19
PMCLAB2019.043 IL-18 as diagnostic biomarker, differentiating systemic juvenile idiopathic arthritis from malignancies Dr. Leek 5-Dec-19
PMCLAB2019.044 Opzetten TMA stainings Dr. Stip 9-May-19
PMCLAB2019.045 Intensive care prevalence, morbidity, and survival in children with Wilms tumor in the Netherlands Dr. Steur 25-Apr-19
PMCLAB2019.046 Incidence, clinical presentation and clinical outcome of invasive fungal diseases in childhood acute lymphoblastic leukemia (IFD ALL-11) Dr. Bury 9-May-19
PMCLAB2019.047 The role for somatic evolution of mesenchymal stromal cells in the development of pediatric acute myeloid leukemia Dr. van Boxtel 9-May-19
PMCLAB2019.048  Immunophenotype ETP-ALL Dr. Cante - Barrett 9-May-19
PMCLAB2019.049 Onderzoek overleving van kinderen met een recidief ALL na stamceltransplantatie  Dr. Prinsze 9-May-19
PMCLAB2019.050 Surgery for Children with Cancer: Experience in a National Pediatric Oncology Center Dr. Tien Lee 20-Jun-19
PMCLAB2019.051 Impact of cytogenetic aberrations on normal hematopoietic stem cells in acute myeloid leukemia.  Dr. Belderbos 23-May-19
PMCLAB2019.052 Prognosis of AML with ‘NUP98-other’ translocations Dr. Goemans 6-Jun-19
PMCLAB2019.053 Comparison of FFPE-derived DNA and cell-free DNA from plasma in patients with pediatric rhabdomyosarcoma Dr. Lak 6-Jun-19
PMCLAB2019.054 Mechanisms of hypermutation in relapsed acute lymphoblastic leukemia in children and implications for treatment Dr. Kuiper 18-Jul-19
PMCLAB2019.055 Bulk and scRNA-seq of paediatric AML samples Prof.dr. Heidenreich 23-Sep-19
PMCLAB2019.056 Congenital cutaneous AML Dr. Goemans 18-Jul-19
PMCLAB2019.057 Ponte di Legno International Collaborative Leukemia Project Retrospective Investigation of NUT Midline Carcinoma Family Member 1 (NUTM1) rearrangements in Infants and Children with ALL Dr. Boer 18-Jul-19
PMCLAB2019.058 The Role of mRNA splicing in Leukemic Stem and Progenitor Cells in Pediatric Acute Myeloid Leukemia Dr. van der Werf 30-Aug-19
PMCLAB2019.061 Prevalence and Determinants of Tinnitus and Hearing Aid Use among 2,948 Dutch Survivors of Childhood Cancer: a DCOG Late-Effects Study Dr. Meijer 15-Aug-19
PMCLAB2019.062 Identifying a second hit in the fumarate hydratase (FH) gene Dr. Hol 15-Aug-19
PMCLAB2019.063 Single cell analysis of pediatric pheochromocytoma Dr. Brazda 15-Aug-19
PMCLAB2019.065 Assessment of cLinical outcome, Epidemiology and Risk factors of renal Toxicity (ALERT studie) Dr. Raymakers-Janssen 29-Aug-19
PMCLAB2019.066 Identifying molecular markers in peripheral blood of patients with pediatric renal tumors Dr. Tytgat 12-Sep-19
PMCLAB2019.067 The metastatic bone marrow niche in Neuroblastoma Dr. Tytgat 12-Sep-19
PMCLAB2019.068  A retrospective analysis of severely delayed methotrexate clearance in children with Acute Lymphoblastic Leukemia(ALL) Dr. Oosterom 26-Sep-19
PMCLAB2019.069 Osteonecrosis in children and adolescents with Philadelphia chromosome positive acute lymphoblastic leukemia(Phi+ALL) treated with tyrosine kinase inhibitors (TKIs) in the EsPhALL protocols: incidence, risk factors, management and outcome. Contribution to a retrospective multicenter study, within the EsPhALL trials Prof.dr. van den Heuvel-Eibrink 26-Sep-19
PMCLAB2019.070 Autologe stamceltransplantatie bij pediatrisch oncologische patiënten; “Poor Mobilisers”, Plerixafor en (PEG)filgrastim Dr. Kraal 26-Sep-19
PMCLAB2019.071 Visual impairment in children with a brain tumor detected via unstructured ophthalmology screening :  a retrospective cohort study Dr. Schouten 10-Oct-19
PMCLAB2019.073 Analysis of CD37 expression in pediatric mature B‐cell lymphomas and correlation with clinical presentation and outcome Dr. Meyer-Wentrup 7-Nov-19
PMCLAB2019.074 The bone marrow niche revisited: secretome profiling of pediatric ALL and AML Prof.dr. den Boer 7-Nov-19
PMCLAB2019.075 Neuroblastoma European Catecholamine Study Dr. Tytgat 24-May-20
PMCLAB2019.076 Physical performance in children with (supra)sellar tumors and hypothalamic dysfunction Dr. Rehorst-Kleinlugtenbelt 21-Nov-19
PMCLAB2019.077 Generation of Hodgkin’s lymphoma organoids for functional studies Dr. Meyer-Wentrup 21-Nov-19
PMCLAB2019.079 CARs for CNS-Leukemia Relapse: A retrospective international study proposal Dr. Vormoor-Burger 5-Dec-19
PMCLAB2019.080 Characteristics of the neuro-vascular unit of the pons in patients suffering from diffuse intrinsic pontine glioma and healthy children Dr. El-Khouly 5-Dec-19
PMCLAB2019.081 Identifying Minimal Residual Disease targets by FUDGE, a rapid Nanopore-sequencing based fusion-gene detection assay Dr. Westera 5-Dec-19
PMCLAB2019.082 Benign and malignant skin disorders in CCS: the LATER SKIN cohort study Prof.dr. Kremer 5-Dec-19
PMCLAB2019.084 Limbic system damage and neuropsychological outcomes in pediatric posterior fossa tumors Dr. Partanen 5-Dec-19
PMCLAB2019.085 Screening of neuropsychological impairments in pediatric brain tumor Dr. Partanen 5-Dec-19
PMCLAB2019.086 Detecting fibronectin splice-variants in osteosarcoma tumors Dr. Janda 19-Dec-19
PMCLAB2019.087 Detection of high risk cancer predisposing genes Dr. Kuiper 13-Feb-20
PMCLAB2020.088 Morphology of Burkitt lymphoma Dr. Vermeulen 16-Jan-20
PMCLAB2020.089 The contribution of surgical clips for optimizing image-guided radiotherapy in pediatric renal tumors: the Utrecht experience Prof.dr. van den Heuvel-Eibrink / Dr. Mul 16-Jan-20
PMCLAB2020.090 In-vitro models for rare pediatric cancers Prof.dr. Clevers / Dr.van de Wetering 30-Jan-20
PMCLAB2020.092 The mutational spectrum of immature T-cell malignancies Dr. Meijerink / Dr. Kroeze 30-Jan-20
PMCLAB2020.093 Full molecular characterization of the Princess Máxima Neuroblastoma cohort Dr. Molenaar /Dr. Langenberg 10-Mar-20
PMCLAB2020.094 Investigating the mutational spectrum of pediatric non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) Prof.dr. Holstege /Dr. Meister 30-Jan-20
PMCLAB2020.095 Risk factors and prognosis of disseminated pediatric low grade glioma Prof.dr. Hoving /Dr. van den Bergen 30-Jan-20
PMCLAB2020.096 The feasibility to make a Neuroblastoma xenograft bearing mouse with intact immune system Dr. Tytgat 30-Jan-20
PMCLAB2020.097 Immunomonitoring: Investigation of efficacy of GM-CSF and G-CSF to activate neutrophils Dr. Tytgat 30-Jan-20
PMCLAB2020.098 Radiotherapy-related meningioma, cerebrovascular events, and cataract in childhood cancer survivors: A Dutch LATER cohort Study project Prof.dr. Kremer 30-Jan-20
PMCLAB2020.099 Health problems after 3D-planned pediatric radiotherapy: A nation-wide cohort study Prof.dr. Kremer 30-Jan-20
PMCLAB2020.100 RNAseq data from neuroblastoma. (Neuroblastoma cell of origin) Prof.dr. Clevers / Dr.van de Wetering 13-Feb-20
PMCLAB2020.101 Cataloguing and characterizing chemotoxicities of B-ALL treatment in Down syndrome children Dr. van Boxtel/ Dr. Hasaart 13-Feb-20
PMCLAB2020.102 An International Study on Pediatric PICALM-MLLT10 + Leukemias Dr. Goemans 13-Feb-20
PMCLAB2020.103 Risk factors and consequences of thyroid dysfunction after treatment for childhood cancer : filling the gaps in evidence needed for new international recommendations. The Dutch LATER cohort  thyroid dysfunction  study. (LATER THYR)  Prof.dr. Kremer/Dr. van Santen 13-Feb-20
PMCLAB2020.104 The incidence of influenza infections and risk factors for severe disease in children with cancer Prof.dr. Tissing 13-Feb-20
PMCLAB2020.105 Validation of the molecular profiling pipeline at the Princess Máxima Center within the Princess Máxima Center precision medicine program iTHER Dr. Molenaar 23-Mar-20
PMCLAB2020.106 Identification of genomic signatures predictive of AML outcome in paediatric patients Prof.dr. Zwaan 27-Feb-20
PMCLAB2020.107 Towards understanding pediatric liver tumors Dr. Peng 27-Feb-20
PMCLAB2020.108 The validation of the SARC-F child: a screenings tool in pediatric oncology Prof.dr. van den Heuvel-Eibrink 27-Feb-20
PMCLAB2020.109 Adult growth hormone deficiency in childhood cancer survivors. Prof.dr. van den Heuvel-Eibrink 18-Jun-20
PMCLAB2020.110 Metabolic syndrome in childhood cancer survivors (DCOG LATER METS study) Prof.dr. van den Heuvel-Eibrink 18-Jun-20
PMCLAB2020.111 Frailty, impaired bone mineral density, fractures and follow-up of osteonecrosis in childhood cancer survivors (DCOG LATER BONE study) Prof.dr. van den Heuvel-Eibrink 18-Jun-20
PMCLAB2020.112  Mutational dynamics between primary and relapse tumors of patients within the Princess Máxima Center precision medicine program iTHER Dr. Molenaar 3-Apr-20
PMCLAB2020.113 Creation of a Tissue Micro-Array of primary Neuroblastoma samples Dr. Molenaar 27-Feb-20
PMCLAB2020.114 Identifying the causal mechanism behind (no-known-driver) pediatric acute myeloid leukemia Dr. van Boxtel 12-Mar-20
PMCLAB2020.116 Fusion gene detection using nanopore sequencing Dr.Tops/ Dr. Monroe 12-Mar-20
PMCLAB2020.118 FFPE-derived DNA for target identification in cell-free DNA in patients with neuroblastoma Dr. Tytgat 12-Mar-20
PMCLAB2020.119 A nationwide descriptive study of genetic predisposition in children with cancer: evaluation of diagnostic processes and consequences for clinical management Dr. Kuiper/Dr. Jongmans 26-Mar-20
PMCLAB2020.120 Presence of scRNA sequencing markers in neuroblastoma patients Prof.dr. Clevers / Dr.van de Wetering 26-Mar-20
PMCLAB2020.121 Benefits and limitations of implementation of a clinical decision support system (CDSS) to optimize drug dosing in paediatric oncology patients with impaired renal function (SIGNPOST) Dr. Muilwijk 26-Mar-20
PMCLAB2020.122 Cerebrospinal fluid leakage after intradural surgery in the pediatric population – A retrospective cohort study Prof.dr. Hoving 9-Apr-20
PMCLAB2020.123 A descriptive study of gliomas in children with Li Fraumeni syndrome Dr. Jongmans 9-Apr-20
PMCLAB2020.124 Tumor-infiltrating lymphocytes in Neuroblastoma Dr.Molenaar/Dr.Tytgat/Dr.van Noesel 16-Apr-20
PMCLAB2020.125 Effects of different formulations on Standardised Uptake Value measurements in Pediatric PET imaging Dr. Merks/ Dr. de Keizer 23-Apr-20
PMCLAB2020.126 Clinical outcome of second relapsed and refractory first relapsed pediatric AML. A retrospective study within the NOPHO-DB SHIP consortium Prof.dr. Kaspers 23-Apr-20
PMCLAB2020.127 Training MRI data for development of a semi-automated MRI analysis tool; part of the  international retrospective DW-MRI rhabdomyosarcoma study project Dr. Merks 23-Apr-20
PMCLAB2020.128 Exploring the origin of extramedullary pediatric acute myeloid leukemia. Dr. van Boxtel 7-May-20
PMCLAB2020.129 Detection of cell surface antigens in rhabdomyosarcoma Dr. Janda 7-May-20
PMCLAB2020.130 Patient-derived models to study disease biology and the therapeutic potential of gene therapy in Diamond-Blackfan Anemia.   Dr. de Haas 26-May-20
PMCLAB2020.131 Longitudinal patterns of quality of life during and after cancer treatment  Dr. Partanen/ Prof. dr. Grootenhuis 25-May-20
PMCLAB2020.132 Germline PAX5 alterations in pediatric ALL Dr. Kuiper/Dr. Jongmans 25-May-20
PMCLAB2020.133 DMTR: Dutch Melanoma Treatment Registry Dr. Zsiros 22-Jun-20
PMCLAB2020.134 Characteristics and outcome of children with renal tumors in the Netherlands, the first full five years experience of national centralization in the Princess Máxima Center for pediatric oncology, a descriptive national study. Prof.dr. van den Heuvel-Eibrink 4-Jun-20
PMCLAB2020.135 Functional analyses of leukaemic lineage switches and MPALs Prof.dr. Heidenreich 4-Jun-20
PMCLAB2020.136 Extracellular vesicles in patients with neuroblastoma: standardization and characterization  Dr. Tytgat 22-Jun-20
PMCLAB2020.137 TransExpo: International Study of Childhood Leukemia and Residences Near Electrical Transformer Rooms Dr. Karim 18-Jun-20
PMCLAB2020.139 Natural history and prognostic factors of incidentelomas Prof.dr. Hoving 18-Jun-20
PMCLAB2020.141 Targeting the central nervous system in MLL-rearranged infant acute lymphoblastic leukemia Dr. Stam 18-Jun-20
PMCLAB2020.142 Pediatric brain tumor research at the Princess Maxima Center Dr. Kool 2-Jul-20
PMCLAB2020.143 Psychosocial functioning of Dutch children with cancer and their parents during the COVID-19 pandemic Prof.dr. Grootenhuis 18-Jun-20
PMCLAB2020.144 Analysis of markers of neurons in the adult human adrenal medulla Dr. Molenaar 18-Jun-20
PMCLAB2020.145 Identifying cause of therapy failure in BCR-ABL 1 positive and BCR-ABL 1-like ALL. Prof.dr. den Boer 2-Jul-20
PMCLAB2020.146 Clostridioides difficile in pediatric cancer and hematopoietic stem cell transplantation. Prof.dr. Tissing 2-Jul-20
PMCLAB2020.148 Brain tumors in pediatric patients with neurofibromatosis type 1 in care or follow-up in a national pediatric oncologic center (a cohort study). Prof.dr. Hoving 2-Jul-20
PMCLAB2020.149 Further development of kidney organoid culture: towards clinical applications Dr. Drost 2-Jul-20
PMCLAB2020.150 Filling the gaps in evidence on prevalence, risk and surveillance for thyroid nodules and thyroid cancer in childhood cancer survivors (LATER THYR II). Prof.dr. Kremer 4-Aug-20
PMCLAB2020.151 Identifying the mechanisms underlying therapy-related pediatric AML. Dr. van Boxtel 16-Jul-20
PMCLAB2020.152 Added value of ASL perfusion MRI and 1H MRS in diagnosing  and follow up of children with a brain tumor Prof.dr. Hoving 16-Jul-20
PMCLAB2020.153 Genomic analysis of myofibromatosis. Dr. Merks 16-Jul-20
PMCLAB2020.154 Cell free detection of hypermethylated RASSF1A in pediatric solid tumors. Dr. Tytgat 16-Jul-20
PMCLAB2020.155 Ponte di Legno International Collaborative Leukemia Project; Retrospective investigation of tumor genetics in children with ETV6-RUNX1 positive ALL Prof.dr. Pieters/Prof.dr. den Boer 16-Jul-20
PMCLAB2020.156 A retrospective analysis of the effect of inotuzumab ozogamicin on CAR-T cell treatment in B-cell precursor ALL. Prof.dr. Zwaan 16-Jul-20
PMCLAB2020.157 Testis Sparing Surgery in Pediatric Testicular Tumors Prof.dr. van Noesel 16-Jul-20
PMCLAB2020.158 Development of an in vitro  culture system for pre-pubertal spermatogonial stem cells. Dr. Looijenga 16-Jul-20
PMCLAB2020.160 Detection of mutational processes in acute lymphoblastic leukemia Dr. Kuiper 16-Jul-20
PMCLAB2020.161 Improving diagnostics and therapy response of TP53 aberrant ALL Dr. van Leeuwen/ Dr. Kuiper 16-Jul-20
PMCLAB2020.162 Risk and time trends of subsequent tumors after five decades of pediatric cancer treatment Prof.dr. Kremer 27-Aug-20
PMCLAB2020.163 Imaging features of hepatic sinusoidal obstruction syndrome or veno-occlusive disease in children –a pictorial essay Prof.dr. van Noesel 27-Aug-20
PMCLAB2020.164 Unraveling the immune microenvironment of ependymomas Prof.dr. Hoving 27-Aug-20
PMCLAB2020.165 Immunoglobulin and T-cell receptor rearrangement detection in RNAseq, WES and WGS datasets Dr. Tops 10-Sep-20
PMCLAB2020.168 Lineage cell tracing in histiocytosis patients Prof.dr. Heidenreich 24-Sep-20
PMCLAB2020.170 Completing the information database of Nijmegen patient samples Dr. Kuiper 8-Oct-20
PMCLAB2020.171  DWI-MRI based personalized tumor discrimination in children with renal tumors.  Prof.dr. van den Heuvel-Eibrink 8-Oct-20
PMCLAB2020.172 Impact of Conditioning, Graft Manipulation and Source on Outcomes after Transplantation for Fanconi anemia Dr. Bierings 8-Oct-20
PMCLAB2020.173 Panel-of-normals for copy number and structural variant detection in WES and WGS data Dr. Kuiper 8-Oct-20
PMCLAB2020.174 Develop and validate a pharmacokinetic model for high-dose methotrexate and quantification of the exposure-toxicity relationship in order to better predict and prevent severe methotrexate toxicity. Dr. Hanff 22-Oct-20
PMCLAB2020.175 MRI changes after proton and photon therapy for primary pediatric CNS tumors in The Netherlands. Prof.dr. Hoving 30-Oct-20
PMCLAB2020.176 Pediatric T-cell Acute Lymphoblastic Leukemia in the Netherlands: a population-based study over a 40 year period Prof.dr. Pieters 27-Oct-20
PMCLAB2020.177 Health-related quality of life and its determinants in pediatric acute myeloid leukemia Prof.dr. Grootenhuis 22-Oct-20
PMCLAB2020.178 Survival outcomes after relapse of myeloid leukemia in children with down syndrome Dr. Goemans 21-Dec-20
PMCLAB2020.179 Immunohistochemical evaluation of CD99, CXCR4, NPY-R-Y1, LINGO-1, IGF-1R, C-Kit (CD117), NOTCH-R, Occludin and Claudin-1 for fluorescence-guided surgery (FGS) of Ewing sarcoma. Prof.dr.Wijnen 19-Nov-20
PMCLAB2020.180 Registry of Chimeric Antigen Receptor T cell recipients with SARS-CoV-2 infection  Prof.dr. Vormoor 18-Nov-20
PMCLAB2020.181 Clinical course and molecular characterization of a retrospective nation-wide cohort of Dutch pediatric CNS germ cell tumors Dr. Looijenga 5-Nov-20
PMCLAB2020.182 Histological and molecular characterization of extracranial germ cell tumors: towards an optimal patient risk stratification. Dr. Looijenga 5-Nov-20
PMCLAB2020.183 ABDOMINAL NEUROBLASTOMA – Estimation of the clinical benefit of proton therapy based on literature review with validation of the Dutch single center cohort 2015-2020. Prof.dr. van Noesel 5-Nov-20
PMCLAB2020.184 Isolation of mesenchymal stromal cells and haematopoietic stem and progenitor cells from human bone marrow Prof.dr. Heidenreich 19-Nov-20
PMCLAB2020.185 CloFluBu conditioning in HCT for pediatric leukemia Dr. Bierings 5-Nov-20
PMCLAB2020.186 Time trends in incidence and survival of thyroid carcinoma in children, adolescents and young adults (0-24 years) in the Netherlands, 1990-2018 Prof.dr. van Noesel 19-Nov-20
PMCLAB2020.187 Survival of children, and adolescents and young adults (AYAs) with acute myeloid leukemia (AML) in the Netherlands Prof.dr. Zwaan 19-Nov-20
PMCLAB2020.188 The thymus as resource of mediastinal germ cell tumors.   Dr. Looijenga 19-Nov-20
PMCLAB2020.190 Identification of novel tumor-specific proteins and epitopes across pediatric tumor types Dr. van Heesch 3-Dec-20
PMCLAB2020.191 Time trends in incidence, stage at diagnosis, treatment and survival of sarcomas diagnosed in children and young adolescents (<18 years) in the Netherlands, 1990-2019 Dr. Merks 3-Dec-20
PMCLAB2020.193 Treatment with chemotherapy in (relapse/progressive) pilocytic astrocytome: a multicenter retrospective cohort study. Prof.dr. Hoving 21-Dec-20
PMCLAB2020.194 Outcome for children with acute myeloid leukemia in the Netherlands following initial treatment between 1998 and 2018 Prof.dr. Zwaan 10-Dec-20
PMCLAB2020.195 Uitkomsten van directe lijn wissels versus een lijnvrij interval na centrale lijn verwijdering i.v.m. een centrale lijn geassocieerde bloedbaan infectie in kinderoncologie patiënten. Prof.dr.Wijnen 17-Dec-20
PMCLAB2020.196 Dose-evaluation of antifungal treatment with isavuconazole in pediatric oncology patients (DEFINE) Prof.dr. Tissing 17-Dec-20
PMCLAB2021.199 Imaging of neuroblastoma and correlation with other diagnostic techniques Dr. Tytgat 7-Jan-21
PMCLAB2021.200 Cancer penetrance in patients with germline pathogenic variants in SMARCA4 Dr. Jongmans 7-Jan-21
PMCLAB2021.201 Hypothalamic function and its relation to BMI change in children with brain tumors Prof. Dr. Tissing 7-Jan-21
PMCLAB2021.202 Evaluation of b-SSFP as non-contrast MRA for surgical planning of Wilms tumour surgery Prof. Dr. Wijnen 7-Jan-21
PMCLAB2021.203 Machine learning based MRI segmentation for 3D visualization in Wilms tumor planning Prof. Dr. Wijnen 7-Jan-21
PMCLAB2021.204 Improved histological and molecular characterization of pediatric central nervous system tumors Dr. Tops 21-Jan-21
PMCLAB2021.206 The role of functional imaging (FDG-PET and DW-MRI) in children and adolescents with an osteosarcoma or Ewing sarcoma Dr. Merks 21-Jan-21
PMCLAB2021.207 Communication in the AML niche and its impact on treatment response Prof. Dr. Heidenreich 4-Feb-21
PMCLAB2021.208 Risk of Central-Line Associated Bloodstream Infections in Pediatric Neuroblastoma Patients Receiving Immunotherapy Prof. Dr. Wijnen 21-Jan-21
PMCLAB2021.209 Early detection of lymphoma in CMMRD and AT patients Dr. Kuiper 4-Feb-21
PMCLAB2021.210 The transition of lymphoblastic malignancies: when does leukemia become lymphoma and vice versa? Dr. Meijerink 4-Feb-21
PMCLAB2021.211 Predictors for malignancy in children with lymphadenopathy Dr. Meyer-Wentrup 4-Feb-21
PMCLAB2021.212 MRD monitoring during maintenance in pediatric patients with acute lymphoblastic leukemia Prof. Dr. Pieters 18-Feb-21
PMCLAB2021.214 Investigating the relationship between RNA alterations and upstream genomic events in pediatric cancer Dr. Kemmeren 18-Feb-21
PMCLAB2021.215 RNA-seq based tumor classification for a broad range of pediatric cancer types Dr. Kemmeren 18-Feb-21
PMCLAB2021.216 Detection and monitoring of cell free tumor DNA in plasma of infants with KMT2A-rearranged ALL Prof.dr. Pieters 4-Mar-21
PMCLAB2021.217 Clinical relevance of a hotspot at the central venous access device tip on FDG PET-CT in pediatric oncology patients Prof.dr. Pieters 4-Mar-21
PMCLAB2021.218 Efficacy of Imatinib in ABL-class fusion positive ALL Prof.dr. den Boer 4-Mar-21
PMCLAB2021.219 Proposal for use of biobank patient materials for dedicated study related to patientcare Dr. Tops/Dr. de Haas 4-Mar-21
PMCLAB2021.220 Immunofluorescent evaluation of CXCR4, NCAM, Jagged1, GJA-1 and Cadherin11 for fluorescence-guided surgery (FGS) of Wilms tumor Prof.dr. Pieters 18-Mar-21
PMCLAB2021.221 A retrospective study on the use of CAR T-cells after Inotuzumab Ozogamicin treatment in children with relapsed or refractory acute lymphoblastic leukemia (ALL) Prof.dr. Zwaan 18-Mar-21
PMCLAB2021.222 Palliative Care in a National Pediatric Oncology Center in the Netherlands: results of the first 18 months Prof.dr. Tissing 18-Mar-21
PMCLAB2021.223 Evaluation of risk stratification based on genetic markers of ALL cases in the ALLTogether protocol Prof.dr. den Boer 18-Mar-21
PMCLAB2021.224 Retrospective analysis of treatment outcomes of acute promyelocytic leukemia in Dutch children from 2005 until 2021 Prof.dr. Kaspers 1-Apr-2021
PMCLAB2021.225 Regeneration of the human hematopoietic stem cell niche after transplantation Dr. Belderbos 1-Apr-2021
PMCLAB2021.226 Getting on my nerves: Neural regulation of human hematopoietic stem cells Dr. Belderbos 1-Apr-2021
PMCLAB2021.228 Tumor-specific transcripts as novel biomarkers and immunotherapy targets for pediatric cancer Dr. van Heesch 15-Apr-2021
PMCLAB2021.229 Evolutionarily young microproteins in childhood brain cancer Dr. van Heesch 1-Apr-2021
PMCLAB2021.230 Incidence of (Viridans Group Streptococci) bloodstream infections in children with acute myeloid leukemia treated at the Dutch Princess Máxima Center for Pediatric Oncology Prof.dr. Kaspers 1-Apr-2021
PMCLAB2021.231 Is partial nephrectomy possible? An analysis of MRI imaging pre- and post-chemotherapy Prof.dr. Pieters 15-Apr-2021
PMCLAB2021.232 Identification of a pLGG relevant MAPK activity score to predict response to MAPKi Prof.dr. Hoving 15-Apr-2021
PMCLAB2021.233 De meerwaarde van het scannen van een MRI craniospinale as bij follow up van kinderen met een medulloblastoom, een retrospectief onderzoek.  Prof.dr. Hoving 29-Apr-2021
PMCLAB2021.234 Risk of second cancers in pediatric Hodgkin lymphoma patients: effects of treatment, age at diagnosis and attained age. Prof.dr. Kremer 20-Mei-2021
PMCLAB2021.235 Risk factors for organ dysfunction and adverse outcome in pediatric oncology patients admitted to the pediatric intensive care unit Prof.dr. Tissing 29-Apr-2021
PMCLAB2021.236 Pharmacogenetics in Pediatric Oncology: a case report of 10 patients   Dr. Huitema 29-Apr-2021
PMCLAB2021.237 Extent of resection in relation to anatomical location of pediatric brain tumors  Prof.dr. Hoving 20-Mei-2021
PMCLAB2021.238 Uncovering the spatial immune landscape in AML and “normal” hematopoiesis  Prof.dr. Heidenreich 20-Mei-2021
PMCLAB2021.239 AML Data commons, data request for the DB-AML01 protocol data Prof.dr. Zwaan 27-Mei-2021
PMCLAB2021.240 iTHER 2.0: Clinical implementation of a pediatric cancer precision medicine program, enforced with personalized models Prof.dr. Zwaan 20-Mei-2021
PMCLAB2021.241 Diffusion MRI in pediatric posterior fossa brain tumors  Prof.dr. Hoving 20-Mei-2021
PMCLAB2021.242 Using Whole Exome Sequencing for Pharmacogenetic Screening in Pediatric Oncology Dr. Huitema 20-Mei-2021
PMCLAB2021.243 Expression data analysis to identify markers associated with extramedullary disease in ALL Dr. Tops 10-Jun-2021
PMCLAB2021.244 Therapeutic drug monitoring of itraconazole and its main metabolite administered as prophylaxis in pediatric oncology patients  Dr. Hanff 10-Jun-2021
PMCLAB2021.245 Reducing survival disparities between pediatric, adolescent, and young adult patients with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in the Netherlands Prof.dr. Zwaan 5-Aug-2021
PMCLAB2021.246 Validation of cell-state marker genes identified by single-cell RNA-sequencing of rhabdomyosarcoma tumors Prof.dr. Holstege 10-Jun-2021
PMCLAB2021.247 Treatment effect and toxicity evaluation of bevacizumab for progressive optic pathway glioma: a retrospective multicenter study Prof.dr. Hoving 10-Jun-2021
PMCLAB2021.248 RNA-Based Diagnostic Tool for Pediatric MDS Dr. Belderbos 8-Jul-2021
PMCLAB2021.249 Deciphering heterogeneity in T-ALL Dr. Meijerink 13-Sept-2021
PMCLAB2021.251 Identification of residual T-ALL blasts in expanded ‘healthy’ T-cell subsets  Dr. Meijerink 5-Aug-2021
PMCLAB2021.252 A patient with second T-ALL with unique locations of the STIL-TAL1 fusion breakpoints at first and second leukemia presentation Dr. Kuiper 5-Aug-2021
PMCLAB2021.253 Second line therapy outcomes in pediatric acute Graft-versus-host disease (STOPGvHD) Dr. Lindemans 27-Sept-2021
PMCLAB2021.254 Characterization of Hodgkin lymphoma tumor cells and their microenvironment  Dr. van Boxtel 8-Jul-2021
PMCLAB2021.255 Prevalence and risk factors for taste alterations and nausea in children with cancer and the impact of these symptoms on Health Related Quality of Life (HRQoL) Prof.dr. Tissing 8-Jul-2021
PMCLAB2021.256 International benchmarking of childhood cancer survival by tumour stage (BENCHISTA) Dr. Karim 5-Aug-2021
PMCLAB2021.257 Survival and Prognostic Factors of Early Childhood Medulloblastoma: An International Meta-Analysis  Prof.dr. Hoving 5-Aug-2021
PMCLAB2021.258 Retrospective analysis of RNAseq data from newly diagnosed and relapsed ALL and AML patients to develop insight and testable hypotheses on the communication of the leukemic cells with their microenvironment  Prof.dr. den Boer 5-Aug-2021
PMCLAB2021.259 Mutant BRAF allele burden in relation to clinical outcome: a multi-centre ECHO project  Prof.dr. Heidenreich 5-Aug-2021
PMCLAB2021.260 Spatial transcriptomic landscapes of high-grade pediatric brain tumors  Prof.dr. Stunnenberg 30-Aug-2021
PMCLAB2021.261 Request on data on Ectomesenchymoma Dr. Merks 19-Aug-2021
PMCLAB2021.262 Multifactorial risk stratification for pediatric RMS Prof.dr. Holstege 19-Aug-2021
PMCLAB2021.263 Defining central-line associated and central line related bloodstream infection in the hemato-oncological population Prof.dr. Wijnen 13-Sept-2021
PMCLAB2021.264 Prognostic factors for survival after relapse in pediatric medulloblastoma: a retrospective Dutch cohort study Prof.dr. Hoving 13-Sept-2021
PMCLAB2021.265 Investigating the clonal evolution of de novo pediatric AML Dr. van Boxtel 13-Sept-2021