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Jeff DeMartino

PhD Student
Jeff DeMartino
Jeff DeMartino
Jeff is PhD student in de Holstege groep.

The aim of my PhD projects is to improve our understanding of pediatric soft tissue sarcomas, with a focus on rhabdomyosarcoma (RMS), using advanced molecular and cell biological techniques. These include using single-cell RNA-sequencing to investigate the cellular and transcriptional heterogeneity in RMS tumors, as well as CRISPR-based genetic screens to define novel therapeutic targets.

  • Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

    • okt. 2023
    • Lin, Lin, et al
    • Science
  • Multi-dimensional profiling of hepatoblastomas and patient-derived tumor organoids uncovers tumor subpopulations with divergent WNT activation profiles and identifies pan-hepatoblastoma drug sensitivities

    • jan. 2023
    • Thomas, Kluiver, et al
    • bioRxiv
  • Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

    • jan. 2023
    • Jeff, DeMartino, et al
    • Nature communications
  • Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

    • dec. 2022
    • Gui Wei, He, et al
    • Cell Stem Cell
  • Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

    • sep. 2022
    • Gui Wei, He, et al
    • Cell Stem Cell
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