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Leukemia

Here you will find short summaries of selected publications regarding leukemia.
Acute lymphoid leukemia (ALL)


Detailed analysis of a high-risk form of ALL (Den Boer et al, 2021)
Children with rare aberrations in genes of the so-called ABL-class have a higher risk of recurrence.

Inotuzumab ozogamicin in relapsed or refractory ALL (Brivio et al., 2020)
A new drug shows promising activity in an early-phase study in a small number of children.

 

Acute myeloid leukemia (AML)


ACCELERATE: stimulating the development of medicinal products for children with AML (Pearson et al., 2020)
Novel anticancer agents that have been developed for adults are not always suitable for use in children, although new medicines are urgently needed.

FLT3 inhibitors in the treatment of AML (Zwaan et al., 2018) Mutations in the FLT3-gene confer a poor prognosis in children with AML. Targeted inhibition of FLT3 may be a promising strategy for treatment.

Can progression from transient myeloid disease to AML be prevented in children with Down syndrome ? (Flasinski et al., 2018) Treatment with low-dose cytarabine prevents early death from leukemia.

Clofarabine, cytarabine and liposomal daunorubicin for relapsed AML (Van Eijkelenburg et al., 2018) A new combination of chemotherapeutic agents was well tolerated and showed high response rates.

 

Chronic myeloid leukemia (CML)

Dasatinib is safe and active in pediatric CML (Gore et al., 2018)
Children who received the drug dasatinib achieved rapid and deep responses, also those who were resistant or intolerant to the drug imatinib.