Who can enter
- Children with (suspected) neuroblastoma
- 0-18 years of age
Goal
The goal of this study is to compare the short-term safety and tolerability of the 68Ga-SATO scan with the current MIBG scan.
Background
In about 80% of children with neuroblastoma, the disease is visible on an MIBG scan, but in about 20% it is not. So not everyone can be monitored with an MIBG scan and besides that, there are several disadvantages to the MIBG scan.
The SATO scan is a more targeted NBL imaging technique that targets a property of NBL, namely the presence of a protein called SSTR (somatostatin receptor). In this study, children will get a 68Ga-SATO PET/CT scan in addition to the standard MIBG scan.
To do this, the child will receive a single bolus injection of the SATO through a pre-existing intravenous cannula or through a pre-existing central line. Ideally, the PET/CT scan should be performed in the same anesthesia session (only in children requiring sedation) as the MIBG scan, the standard diagnostic examination. This extends anesthesia time by 30-40 minutes and does not require additional insertion of an intravenous cannula (for this examination).
Alternative logistically acceptable arrangements are: (a) the 68Ga-SATO PET/CT scan is done on the day of MIBG injection (day prior to MIBG scan; not for children requiring anesthesia) or on the day of an MRI (for patients requiring anesthesia), (b) a separate scan day, not in combination with the standard diagnostic MIBG scan or MRI, as long as the MIBG scan and the 68Ga-SATO PET/CT scan are no more than two weeks apart (only for children not requiring anesthesia).