Our website uses cookies. We use cookies to remember settings and to help provide you with the best experience we can. We also use cookies to continuously improve our website by compiling visitor statistics. Read more about cookies

GAP-NBL (neuroblastoma)

Clinical study of the short-term safety and tolerability of the 68Ga-SATO scan in children with or suspected neuroblastoma.
Who can enter
  • Children with (suspected) neuroblastoma
  • 0-18 years of age


The goal of this study is to compare the short-term safety and tolerability of the 68Ga-SATO scan with the current MIBG scan.


In about 80% of children with neuroblastoma, the disease is visible on an MIBG scan, but in about 20% it is not. So not everyone can be monitored with an MIBG scan and besides that, there are several disadvantages to the MIBG scan.

The SATO scan is a more targeted NBL imaging technique that targets a property of NBL, namely the presence of a protein called SSTR (somatostatin receptor). In this study, children will get a 68Ga-SATO PET/CT scan in addition to the standard MIBG scan.

To do this, the child will receive a single bolus injection of the SATO through a pre-existing intravenous cannula or through a pre-existing central line. Ideally, the PET/CT scan should be performed in the same anesthesia session (only in children requiring sedation) as the MIBG scan, the standard diagnostic examination. This extends anesthesia time by 30-40 minutes and does not require additional insertion of an intravenous cannula (for this examination).

Alternative logistically acceptable arrangements are: (a) the 68Ga-SATO PET/CT scan is done on the day of MIBG injection (day prior to MIBG scan; not for children requiring anesthesia) or on the day of an MRI (for patients requiring anesthesia), (b) a separate scan day, not in combination with the standard diagnostic MIBG scan or MRI, as long as the MIBG scan and the 68Ga-SATO PET/CT scan are no more than two weeks apart (only for children not requiring anesthesia).

In order to participate in a study please refer to your/your child’s doctor.

Last reviewed

March 3, 2023