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Demi de Winter

MD PhD student
Bone toxicity and body composition during and after treatment for childhood cancer.

The survival rates of patients with childhood cancer have substantially improved over the last decades. The number of long-term childhood cancer survivors has increased, therefore insights in the long-term sequelae of childhood cancer survivors become increasingly important. Osteonecrosis and low bone mineral density (BMD) are serious osteogenic side effects that can occur during or after acute lymphoblastic leukemia (ALL) treatment. Moreover, childhood cancer survivors also carry an increased risk for dysregulation of body-composition, which contributes to metabolic syndrome and increases the risk of cardiovascular disease. During this PhD project, we focus on the direct and long-term bone toxicity and altered body composition following childhood cancer treatment.

  • Prevalence, risk factors, and optimal way to determine overweight, obesity, and morbid obesity in the first Dutch cohort of 2338 long-term survivors of childhood cancer

    • jan. 2023
    • Vincent G, Pluimakers, et al
    • European journal of endocrinology
  • Risk and determinants of low and very low bone mineral density and fractures in a national cohort of Dutch adult childhood cancer survivors (DCCSS-LATER)

    • jan. 2023
    • , et al
    • The Lancet Diabetes and Endocrinology
  • The variable biological signature of refractory cytopenia of childhood (RCC), a retrospective EWOG-MDS study

    • sep. 2021
    • Demi T.C., de Winter, et al
    • Leukemia Research
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