Group leader: Prof.dr. M.M. van den Heuvel-Eibrink
Renal tumors:
Research is focused on clinical outcome determinants for survival and toxicity after childhood renal cancer, including Wilms tumors, as well as rare non-Wilms tumors. The research projects aim for diagnostic innovation (radiology, diagnostic discriminating molecular biomarker identification), oncogenetic characterization (genotype-phenotype correlation and identification of renal tumor-susceptibility), molecular tumor characterization (NGS, organoids, and target identification, compound screens), and innovative treatment development (chemotherapy, immunotherapy, radiotherapy and surgical treatment).
Quality of cure and toxicity research:
The group of Prof. Dr. van den Heuvel-Eibrink focus on the identification of (genetic) determinants of early and late toxicity of childhood cancer, especially endocrine sequelae, and ototoxicity. Research projects are specifically focused on frailty, osteoporosis, fertility and ototoxicity, including tinnitus and hearing loss. The study results contribute to development of international surveillance guideline and intervention studies. In addition to toxicity following childhood cancer, Prof. Dr. van den Heuvel-Eibrink is involved in the outpatient expertise center on Cancer In Pregnancy (CIP), aiming to develop clinical guidelines, so physicians can treat pregnant women with a cancer diagnosis more targeted, and reduce its possible effects on the child’s outcome.
Hol Janna A., Kuiper Roland P., Van Dijk Freerk, Waanders Esmé, Van Peer Sophie E., Koudijs Marco J., Bladergroen Reno, Van Reijmersdal Simon V., Morgado Lionel M., Bliek Jet, Lombardi Maria Paola, Hopman Saskia, Drost Jarno, De Krijger Ronald R., Van Den Heuvel-Eibrink Marry M., Jongmans Marjolijn C.J. Prevalence of (Epi)genetic Predisposing Factors in a 5-Year Unselected National Wilms Tumor Cohort:A Comprehensive Clinical and Genomic Characterization. 10 Jun 2022, Journal of Clinical Oncology. 40 , p. 1892-1902 11 p.
Meijer AJM, van den Heuvel-Eibrink MM, Brooks B, et al. Recommendations for Age-Appropriate Testing, Timing, and Frequency of Audiologic Monitoring During Childhood Cancer Treatment: An International Society of Paediatric Oncology Supportive Care Consensus Report. JAMA Oncol. 2021;7(10):1550–1558. doi:10.1001/jamaoncol.2021.2697.
Van Assche, I. A., Huis In't Veld, E. A., Van Calsteren, K., van Gerwen, M., Blommaert, J., Cardonick, E., ... & Amant, F. (2023). Cognitive and Behavioral Development of 9-Year-Old Children After Maternal Cancer During Pregnancy: A Prospective Multicenter Cohort Study. Journal of Clinical Oncology, JCO-22.
van den Heuvel-Eibrink MM, Hol JA, Pritchard-Jones K, van Tinteren H, Furtwängler R, Verschuur AC, Vujanic GM, Leuschner I, Brok J, Rübe C, Smets AM, Janssens GO, Godzinski J, Ramírez-Villar GL, de Camargo B, Segers H, Collini P, Gessler M, Bergeron C, Spreafico F, Graf N; International Society of Paediatric Oncology — Renal Tumour Study Group (SIOP–RTSG). Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol. 2017 Dec;14(12):743-752. doi: 10.1038/nrurol.2017.163. Epub 2017 Oct 31. PMID: 29089605.
van Atteveld JE, de Winter DTC, Pluimakers VG, Fiocco M, Nievelstein RAJ, Hobbelink MGG, de Vries ACH, Loonen JJ, van Dulmen-den Broeder E, van der Pal HJ, Pluijm SMF, Kremer LCM, Ronckers CM, van der Heiden-van der Loo M, Versluijs AB, Louwerens M, Bresters D, van Santen HM, Olsson DS, Hoefer I, van den Berg SAA, den Hartogh J, Tissing WJE, Neggers SJCMM, van den Heuvel-Eibrink MM; Dutch LATER study group. Risk and determinants of low and very low bone mineral density and fractures in a national cohort of Dutch adult childhood cancer survivors (DCCSS-LATER): a cross-sectional study. Lancet Diabetes Endocrinol. 2023 Jan;11(1):21-32. doi: 10.1016/S2213-8587(22)00286-8. Epub 2022 Dec 10. PMID: 36513116.
