PI: Prof.dr. M.M. van den Heuvel-Eibrink
Renal tumors:
Clinical (survival and toxicity) outcome determinants research, diagnostic innovation(radiology, diagnostic discriminating molecular biomarker identification), oncogenetic characterization research (genotype-phenotype correlation and identification of renal tumor-susceptibility), molecular research (NGS, organoids, and target identification, compound screens), innovative treatment development (chemo-, immunotherapy, radiotherapy and surgical treatment), in Wilms tumors, as well as rare non-Wilms tumors.
Quality of cure and toxicity research:
We focus on the identification of (genetic) determinants of early and late toxicity of childhood cancer, especially endocrine sequelae, and ototoxicity. This includes the establishment of the prospective longitudinal Princess Máxima Center cohort CTCAE based toxicity registry, the “Continuous Registration of direct tOxicity by prospective dataWare housiNg (the Princess Máxima Center-CROWN registry)”, and its accompanying research projects, with a special focus on genetic variation. This program includes the development of international guidelines for surveillance and intervention studies.
van den Heuvel-Eibrink MM, Hol JA, Pritchard-Jones K, van Tinteren H, Furtwängler R, Verschuur AC, Vujanic GM, Leuschner I, Brok J, Rübe C, Smets AM, Janssens GO, Godzinski J, Ramírez-Villar GL, de Camargo B, Segers H, Collini P, Gessler M, Bergeron C, Spreafico F, Graf N; Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol. International Society of Paediatric Oncology — Renal Tumour Study Group (SIOP–RTSG).Nat Rev Urol. 2017 Dec;14(12):743-752. PubMed PMID: 29089605
Gooskens SL, Graf N, Furtwängler R, Spreafico F, Bergeron C, Ramírez-Villar GL, Godzinski J, Rübe C, Janssens GO, Vujanic GM, Leuschner I, Coulomb-L'Hermine A, Smets AM, de Camargo B, Stoneham S, van Tinteren H, Pritchard-Jones K, van den Heuvel-Eibrink MM; Position paper: Rationale for the treatment of children with CCSK in the UMBRELLA SIOP-RTSG 2016 protocol.International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP–RTSG).Nat Rev Urol. 2018 Feb 27. PubMed PMID: 29485128
Gooskens SL, Klasson TD, Gremmels H, Logister I, Pieters R, Perlman EJ, Giles RH, van den Heuvel-Eibrink MM.TCF21 hypermethylation regulates renal tumor cell clonogenic proliferation and migration. Mol Oncol. 2018 Feb;12(2):166-179 PubMed PMID: 29080283
M.M. van den Heuvel-Eibrink and Rob Pieters. Steroids and Osteonecrosis Risk in Acute Lymphoblastic Leukemia: ''Take a Break",The Lancet Oncology, 2012, Sep;13(9):855-7. [IF 22.59]. PubMed PMID: 22901621
Marry M. van den Heuvel-Eibrink, Anne-Lotte L.F. van der Kooi, W. Hamish B. Wallace. Ovarian tissue Cryopreservation for young females with cancer: established or experimental? New England Journal of Medicine, 17-14974, 2018 in press.
