Medical advances in pediatric cancer treatment have led to increased survival rates, therefore long-term quality of life becomes an important issue. Previous research has shown that as a consequence of pediatric brain tumors and treatment (surgery, chemotherapy and/or radiotherapy), especially brain tumor survivors are at considerable risk for neurocognitive deficits. The SuSPeCT study aims to get more insight into the development of such deficits, as well as insight into potential predictors such as medical (traumatic) stress and sleep problems. Children between the age of six and sixteen and their parents will be asked to participate in this longitudinal study from fall 2019 to spring 2022. The study is part of protocolized neuropsychological screening for care purposes (Brain Tumor Protocol). Furthermore, an international clinical practice guideline (CPG) for neurocognition will be developed within the international Guideline Harmonisation Group (ighg.org). It addresses surveillance for late effects in childhood and young adult long-term cancer survivors. CPGs are essential as they are considered as powerful tools to improve the quality of care, while reducing variability in daily practice and health care costs.