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Kremer group

The group is focusing on survivorship research, epidemiological studies, and evidence based pediatric oncology. We have expertise in performing large epidemiological studies on cohorts of children with cancer and survivors, and in systematic reviews and guidelines. We quantify the role of cancer treatment and other important risk factors as they impact health and quality of life. Research is embedded in local, national (LATER study group), and international networks.

PI: Prof.dr. Leontien Kremer, pediatrician
Phone 088 97 29 000

Survivorship research

Years after treatment, childhood cancer survivors are at high risk of developing long-term side effects due to their previous cancer treatment. In the Netherlands we have identified more than 12.000 5 years survivors treated for childhood cancer between 1963 and 2012. Our group is focussing on the quantification of this risk and identification of risk factors and potential interventions.

Current topics are:

  • Overall mortality 
  • Overall burden of disease
  • Health care burden/ evaluation of care 
  • Subsequent tumors 
  • Cardiovascular toxicity 
  • Female fertility
  • Male fertility
  • Fatigue 
  • Radiation epidemiology 


"The results of clinical research have to be included in guidelines to improve the quality of care." Prof.dr. Leontien Kremer - PI
Epidemiological trends among children with cancer

Most of the children ≤ 14 years are treated by pediatric oncologists, however for young adolescents (15-17 years) this percentage is around 50%. To get better insight in the progress made against childhood cancer and to detect whether there is room for improvement,  trends in incidence, survival and mortality are studied in collaboration with the Netherlands Cancer Registry.. Our group is focussing on these three outcome measures of cancer burden for children and young adolescents who are diagnosed in the Netherlands since the 1990s.

Systematic reviews and Guidelines

Systematic reviews and guidelines are the cornerstone for patient care and the starting point for new clinical research in pediatric oncology. The editorial base of Cochrane Childhood Cancer, based in the Princess Máxima Center www.childhoodcancer.cochrane.org is responsible for the (inter)national support, the editorial process and the publication in the Cochrane Library (an internet journal IF 6,124) of Cochrane systematic reviews on childhood cancer. Furthermore our group is providing the methodology to develop guidelines in pediatric oncology on surveillance of childhood cancer survivors (www.IGHG.org) and on fertility preservation.


Kremer group