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Judith Wienke

Judith Wienke
Judith Wienke
Neuroblastoma immunology and immunotherapy
Phone 088 97 27 678

The aim of this project is to 1) identify novel targets for immunotherapeutic interventions in neuroblastoma, 2) develop and investigate innovative (combinations of) immunotherapeutic interventions for clinical applicability, with the ultimate goal of introducing novel treatment options for neuroblastoma.

We will investigate the immune environment of neuroblastoma, and possibly other tumors, starting with single cell RNA sequencing and isolation of tumor-infiltrating immune cells to identify novel targets for immunotherapy. Target identification will be aimed at both undermining tumor immune evasion and increasing the anti-tumor effectivity of immune cells. After target validation, different innovative strategies and combinations of immunotherapeutic interventions will be tested; first in vitro on tumor cell lines and organoids, and later in vivo in murine models. Ultimately, effective interventions will be introduced into the clinical trial phase.

  • Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

    • feb. 2024
    • Judith, Wienke, et al
    • Cancer Cell
  • Adoptive cell therapy in paediatric extracranial solid tumours

    • nov. 2023
    • Elisa, Zappa, et al
    • European journal of cancer (Oxford, England : 1990)
  • Three-Dimensional Modeling of Solid Tumors and Their Microenvironment to Evaluate T Cell Therapy Efficacy In Vitro

    • jul. 2023
    • Ronja, Pscheid, et al
    • Journal of Immunology
  • Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch

    • dec. 2022
    • Annelisa M, Cornel, et al
    • Journal for ImmunoTherapy of Cancer
  • T cell interaction with activated endothelial cells primes for tissue-residency

    • sep. 2022
    • Judith, Wienke, et al
    • Frontiers in Immunology
View all publications