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Kirsten Vrenken

Kirsten Vrenken
Kirsten Vrenken
Identifying novel treatment strategies for infant MLL-rearranged acute lymphoblastic leukemia using comprehensive preclinical modeling
Phone 088 972 76 72

While survival rates of children with acute lymphoblastic leukemia (ALL) have improved greatly over the last decades, successful treatment of infants (<1 year of age) diagnosed with MLL-rearranged ALL remains very challenging. These patients frequently relapse, typically while still on treatment, after which they often fail to respond to therapy. Hence, there is an urgent need to develop novel and more effective treatment options for this group of high-risk patients. Within this project, we aim to establish accurate preclinical models to validate and study the efficacy of promising novel therapeutic agents that were previously identified within our group. Additionally, we will use these preclinical models to gain insight into the mechanisms underlying the development of therapy resistance against current therapeutics as well as our novel compounds. Together these approaches will help us develop innovative treatment strategies to enhance the survival chances of MLL-rearranged infant ALL patients, and identify potentially actionable targets for preventing or treating relapsed disease.


  • CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in KMT2A-Rearranged Acute Lymphoblastic Leukemia

    • jan. 2023
    • Pauline, Schneider, et al
    • International journal of molecular sciences
  • High-Throughput Drug Library Screening in Primary KMT2A-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling

    • mrt. 2022
    • Priscilla, Wander, et al
    • Biomedicines
  • Nectin stabilization at adherens junctions is counteracted by Rab5a-dependent endocytosis

    • sep. 2021
    • Pasquale, Cervero, et al
    • European Journal of Cell Biology
  • The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy

    • mrt. 2020
    • Kirsten S, Vrenken, et al
    • Biochimica et biophysica acta. Molecular basis of disease
  • The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression

    • nov. 2016
    • Jeroen, Middelbeek, et al
    • European journal of cell biology
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