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Nienke van Engelen

PhD student
Nienke van Engelen
Nienke van Engelen
Detection of high risk cancer predisposing genes
Phone 088 97 27 682

Recognition of cancer susceptibility in children with cancer is of high clinical significance. It may require modifications in treatment protocols to prevent toxicities or the risk of second malignancies, and cancer surveillance for early detection of malignancies in the child and his or her family members. Unfortunately, in many children in whom a cancer predisposing syndrome (CPS) is suspected, the underlying genetic cause cannot be found. In this study I will use a range of genomic techniques to identify underlying genetic causes in children with cancer with a high suspicion of a cancer predisposing syndrome. These children will be included based on additional features as a family history of cancer, congenital features or other physical signs, or secondary primary malignancies. With this information we expect to identify novel cancer predisposing genes and mechanisms.

  • Molecular analysis of cancer genomes in children with Lynch syndrome

    • apr. 2024
    • Dilys D, Weijers, et al
    • International journal of cancer
  • A novel germline PAX5 single exon deletion in a pediatric patient with precursor B-cell leukemia

    • jan. 2023
    • N, van Engelen, et al
    • Leukemia
  • In Response to: Pediatric Myelodysplastic Syndrome with Germline RRAS Mutation: Expanding the Phenotype of RASopathies

    • mrt. 2022
    • Nienke, van Engelen, et al
    • Journal of pediatric hematology/oncology
  • Constitutional 2p16.3 deletion including MSH6 and FBXO11 in a boy with developmental delay and diffuse large B-cell lymphoma

    • okt. 2021
    • N, van Engelen, et al
    • Familial Cancer
  • Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li–Fraumeni syndrome

    • mei 2021
    • Greta, Winter, et al
    • Leukemia
View all publications