Our website uses cookies. We use cookies to remember settings and to help provide you with the best experience we can. We also use cookies to continuously improve our website by compiling visitor statistics. Read more about cookies

Thijs van den Broek

Intern
Thijs van den Broek
Drug delivery in Diffuse Intrinsic Pontine Glioma: identifying potential new candidates

In Diffuse Intrinsic Pontine Glioma, the blood-brain barrier seems to be a major obstacle preventing delivery of chemotherapeutic agents to the site of the tumor. Convection-enhanced delivery (CED) and high-intensity focused ultrasound (HIFU) are two techniques that have been developed which may assist the delivery of chemotherapeutic agents across the blood-brain barrier. However, it is unclear which chemotherapeutic agents are most suitable in combination with these techniques. This project will focus on determining which potential chemotherapeutic agents are most suitable for either systemic administration, to use in combination with the CED technique, or to use in combination with the HIFU technique.