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Wim de Jonge

Postdoc
  • Single Cell Genomics

Introducing innovative single-cell sequencing technologies at the Single-Cell Genomics Facility 

Pediatric cancers are complex and heterogenous diseases. To understand how these cancers develop, avoid detection by the immune system, and resist treatment, we need to study them one cell at a time. At the Princess Máxima Center, we use advanced single-cell genomics technologies to closely look at individual cells within a tumor. This allows us to discover details that would be missed when studying the cancer as a whole.  

The field of single-cell genomics is an exciting and rapidly evolving field, with constant development of new tools and technologies. With a background in molecular biology and data analysis, I lead the efforts to test, improve, and introduce new techniques in our Single-Cell Genomics Facility.  

With these new technologies, we will be able to better understand the complexity of pediatric cancers, with the ultimate goal of helping to create more effective and targeted treatments for children with cancer. 

  • Transcription factor clusters enable target search but do not contribute to target gene activation

    • jun. 2023
    • Joseph V W, Meeussen, et al
    • Nucleic acids research
  • Following the tracks

    • mei 2022
    • Wim J, de Jonge, et al
    • Biophysical Journal
  • Sequence-Directed Action of RSC Remodeler and General Regulatory Factors Modulates +1 Nucleosome Position to Facilitate Transcription

    • jul. 2018
    • Slawomir, Kubik, et al
    • Molecular Cell
  • Molecular mechanisms that distinguish TFIID housekeeping from regulatable SAGA promoters

    • feb. 2017
    • Wim J., de Jonge, et al
    • EMBO Journal
View all publications