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Jeff DeMartino

PhD Student
Unravelling the heterogeneity of rhabdomyosarcomas

The aim of my PhD projects is to improve our understanding of pediatric soft tissue sarcomas, with a focus on rhabdomyosarcoma (RMS), using advanced molecular and cell biological techniques. These include using single-cell RNA-sequencing to investigate the cellular and transcriptional heterogeneity in RMS tumors, as well as CRISPR-based genetic screens to define novel therapeutic targets.

  • Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids

    • dec. 2024
    • Thomas A., Kluiver, et al
    • Nature communications
  • Human fetal brain self-organizes into long-term expanding organoids

    • feb. 2024
    • Delilah, Hendriks, et al
    • Cell
  • Human fetal brain self-organizes into long-term expanding organoids

    • jan. 2024
    • Delilah, Hendriks, et al
    • Cell
  • Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

    • dec. 2023
    • Jeff, DeMartino, et al
    • Nature communications
  • Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

    • okt. 2023
    • Lin, Lin, et al
    • Science
View all publications