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  • Jeff DeMartino

Jeff DeMartino

PhD Student
Unravelling the heterogeneity of rhabdomyosarcomas
Phone -
Email j.demartino@prinsesmaximacentrum.nl

The aim of my PhD projects is to improve our understanding of pediatric soft tissue sarcomas, with a focus on rhabdomyosarcoma (RMS), using advanced molecular and cell biological techniques. These include using single-cell RNA-sequencing to investigate the cellular and transcriptional heterogeneity in RMS tumors, as well as CRISPR-based genetic screens to define novel therapeutic targets.

Publications

6 publications in total

  • Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

    • okt. 2023
    • Lin, Lin, et al
    • Science

  • Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

    • jan. 2023
    • Jeff, DeMartino, et al
    • Nature communications

  • Multi-dimensional profiling of hepatoblastomas and patient-derived tumor organoids uncovers tumor subpopulations with divergent WNT activation profiles and identifies pan-hepatoblastoma drug sensitivities

    • jan. 2023
    • Thomas, Kluiver, et al
    • bioRxiv

  • Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

    • dec. 2022
    • Gui Wei, He, et al
    • Cell Stem Cell

  • Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

    • sep. 2022
    • Gui Wei, He, et al
    • Cell Stem Cell
View all publications