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Mirjam Belderbos

Principal Investigator

My research vision is that innovative, fundamental research on hematopoietic stem cell (HSC) biology is required to advance the understanding, care and cure of children suffering from hematologic disease.

Phone 088-9727272

Dr. Belderbos is a principal investigator and pediatric oncologist in hematopoietic stem cell transplantation. After obtaining her PhD in 2012, she moved to Groningen, where she combined clinical training in pediatrics with postdoctoral research at the European Institute for the Biology of Ageing (ERIBA) in Groningen. Here, she pioneered a cellular barcoding method to trace the clonal dynamics of normal hematopoietic stem cells and leukemia in murine xenografts. Her research demonstrated that leukemia contains thousands of leukemia-propagating cells, with selection and evolution characteristic of disease progression. In parallel, she applied cellular barcodes to unravel the frequency and lineage-fate decisions of normal human HSCs. She showed that <1% of cord blood (CB) CD34+ cells produces offspring in murine xenografts, with marked heterogeneity between donors.

In 2017, she joined the Princess Máxima Center as a clinical/research fellow. Here, in collaboration with Ruben van Boxtel, she adopted naturally occurring somatic mutations as “barcodes”, enabling HSC-tracing in human transplantation recipients. The potential of her work is exemplified by my several grants and awards, including a KWF Young Investigator Award (2017) and a Fellowship Award of the European Society for Blood and Marrow Transplantation (2019).

In 2020, dr.Belderbos started her own research group on translational hematopoietic stem cell biology.

  • Leukaemia suppressing normal bone marrow – how long does it last?

    • nov. 2023
    • Mauricio Nicolas Ferrao, Blanco, et al
    • Haematologica
  • A multidimensional analysis reveals distinct immune phenotypes and tertiary lymphoid structure-like aggregates in the bone marrow of pediatric acute myeloid leukemia

    • okt. 2023
    • Joost B, Koedijk, et al
    • medRxiv : the preprint server for health sciences
  • Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox

    • sep. 2023
    • Sjors, Middelkamp, et al
    • Cell genomics
  • Definitions, incidence and outcome of poor graft function after hematopoietic cell transplantation

    • jul. 2023
    • Konradin F, Müskens, et al
    • Blood Reviews
  • Case Report

    • jan. 2023
    • Joost B, Koedijk, et al
    • Frontiers in immunology
View all publications