As a stem cell biologist and clinician working in stem cell transplantation, I want to understand how hematopoietic stem cells produce blood and why they sometimes fail. Although hematopoietic stem cells are the most commonly used type of stem cells for therapy, the mechanisms by which they regenerate all differentiated blood cells are incompletely known. My lab uses various (single-cell) sequencing technologies to study the behavior of human hematopoietic stem cells in health, disease and therapy. Our ultimate goal is to translate fundamental understanding of hematopoietic stem cell biology into novel therapies to benefit patients.
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