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Mirjam Belderbos

Principal Investigator

Understanding human hematopoietic stem cell biology 

Phone 088-9727272

As a stem cell biologist and clinician working in stem cell transplantation, I want to understand how hematopoietic stem cells produce blood and why they sometimes fail. Although hematopoietic stem cells are the most commonly used type of stem cells for therapy, the mechanisms by which they regenerate all differentiated blood cells are incompletely known. My lab uses various (single-cell) sequencing technologies to study the behavior of human hematopoietic stem cells in health, disease and therapy. Our ultimate goal is to translate fundamental understanding of hematopoietic stem cell biology into novel therapies to benefit patients. 

  • Leukaemia suppressing normal bone marrow – how long does it last?

    • nov. 2023
    • Mauricio Nicolas Ferrao, Blanco, et al
    • Haematologica
  • A multidimensional analysis reveals distinct immune phenotypes and tertiary lymphoid structure-like aggregates in the bone marrow of pediatric acute myeloid leukemia

    • okt. 2023
    • Joost B, Koedijk, et al
    • medRxiv : the preprint server for health sciences
  • Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox

    • sep. 2023
    • Sjors, Middelkamp, et al
    • Cell genomics
  • P425: A MULTIDIMENSIONAL AND SPATIAL ANALYSIS REVEALS DISTINCT IMMUNE PHENOTYPES AND SECONDARY LYMPHOID ORGAN-RESEMBLING STRUCTURES IN THE BONE MARROW OF PEDIATRIC ACUTE MYELOID LEUKEMIA

    • aug. 2023
    • Joost, Koedijk, et al
    • HemaSphere
  • Definitions, incidence and outcome of poor graft function after hematopoietic cell transplantation

    • jul. 2023
    • Konradin F, Müskens, et al
    • Blood Reviews
View all publications