Over de past decades childhood cancer survival rates have been increased. Hence, more children suffer from direct and late sequelae of their treatment. Ototoxicity, including hearing loss, tinnitus and vertigo, could be one of the direct sequelae of childhood cancer. Previous studies conclude that treatment with platinum chemotherapeutics, cranial irradiation and ENT surgery may be risk factors for ototoxicity. But, there are also treatment components of which we expect that they contribute to ototoxicity in pediatric patients, like antibiotics and diuretics. In the SOUND study (A prospective Study on prevalence and determinants of Ototoxicity dUring treatmeNt of childhooD cancer) we investigate prevalence and determinants of ototoxicity during treatment of pediatric cancer.
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