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Leukemia

Here you will find summaries of a selection of ongoing clinical trials on leukemia.

Trials with medicinal products


Open for inclusion:

ALLTogether1 (ALL)  Clinical study concerning the ALLTogether1 treatment protocol for children and young adults with acute lymphoblastic leukemia (ALL) - open for inclusion

CABL001i12201 (CML)  Clinical study to determine the dose and safety of asciminib in children and adolescents with chronic myeloid leukemia in the chronic phase - open for inclusion

CASSIOPEIA (B-ALL)  Clinical study with the new tisagenlecleucel treatment in children and adolescents with B-cell acute lymphoblastic leukemia - open for inclusion

CHIP-AML22/Master (Acute Myeloid Leukemia)  Clinical study concerning the treatment of children and adolescents with newly diagnosed acute myeloid leukemia (AML) - open for inclusion

CHIP-AML22/Quizartinib (Acute Myeloid Leukemia)  Clinical study concerning the safety and efficacy of quizartinib in children and adolescents with FLT3-ITD positive AML with normal NPM1 - open for inclusion

ESMART (different tumor types)  Clinical study in children with cancer into the safety and efficacy of drugs matching a specific DNA alteration in the tumor - open for inclusion

HEM-iSMART subprotocol D (ALL/LBL)  Clinical study of trametinib for children with relapsed or refractory leukemia or lymphoma with a RAS mutation - open for inclusion

ICC APL 02 (Acute Promyelocytic Leukemia)  Clinical study of the treatment of Acute Promyelocytic Leukemia (APL) - open for inclusion

Inotuzumab B1931036 (ALL)  Clinical study of inotuzumab ozogamicin in children with a diagnosis of first relapse high-risk acute lymphoblastic leukemia - open for inclusion

Inotuzumab ITCC-059 (ALL/B-cell leukemia/lymphoma)  Clinical study of the safety and efficacy of the drug Inotuzumab Ozogamicin (InO) in children with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL) or other CD22-positive malignancies - open for inclusion

Interfant-21 (ALL)  Clinical study for infants with acute lymphoblastic leukemia with a KMT2A gene rearrangment - open for inclusion

Ponatinib INCB084344 (leukemia/solid tumors)  Clinical study of the safety and efficacy of ponatinib for the treatment of different types of leukemia or solid tumors in children - open for inclusion

Quizartinib (AML)  Clinical study of the safety and efficacy of quizartinib in combination with chemotherapy in children and young adults with AML and FLT3-ITD mutations - open for inclusion

SCRIPT-AML (Stem cell transplantation in Acute Myeloid Leukemia)  Clinical study of conditioning regimen in stem cell transplantation - open for inclusion

SNDX-5613-0700 (relapsed/refractory leukemias)  Clinical study of SNDX-5613 in patients with leukemias - open for inclusion

TCD17197 (R/R AML)  Clinical study of safety and efficacy of the study drug SAR443579 in patients with leukemia - open for inclusion

U-DANCE (acute myeloid leukemia)  Clinical study of the safety and efficacy of a specific vaccine against residual disease after stem cell transplantation in patients with acute myeloid leukemia (AML) - open for inclusion

Venetoclax ITCC-101/APAL2020D (AML)  Clinical study of the efficacy of the drug venetoclax in children and young adults with relapsed AML - open for inclusion

VyClo (ITCC-092) (AML)  Clinical study of the safety of the drug Vyxeos® (liposomal daunorubicin and cytarabine) in combination with clofarabine in children and young adults with relapsed/refractory acute myeloid leukemia (AML) - open for inclusion

ZUMA-4 (ALL/NHL)  Clinical study of the safety and efficacy of KTE-X19 in pediatric and adolescent subjects with relapsed or refractory B-precursor acute lymphoblastic leukemia (ALL) or relapsed or refractory B-cell non-Hodgkin lymphoma (NHL) - open for inclusion

Closed for inclusion/on hold: 

AMoRe2017 (AML)  Clinical study of the safety and efficacy of azacitidine in children and adolescents with a molecular relapse of acute myeloid leukemia (AML) - closed for inclusion

Bosutinib (CML)  Clinical study of the safety and efficacy of bosutinib in children and teenagers with chronic myeloid leukemia (CML) - closed for inclusion

JCAR017-BCM-004 (B-ALL/B-NHL)  Clinical study to evaluate the safety and efficacy of JCAR017 in children with a special type of leukemia (B-ALL) and non-Hodgkin’s lymphoma - closed for inclusion

Venetoclax M13-833 (hematologic/solid tumors)  Clinical study of the safety and efficacy of the drug venetoclax in children and young adults - closed for inclusion

 

 

Other trials


Breath analysis (hemato-oncological disease)  A clinical pilot study of exhaled breath as an approach in the diagnostic work-up for an invasive fungal infection in the lungs of children with an impaired immune system - open for inclusion

DAVINCY (all cancer types)  Clinical study of extended use of the drug (fos)aprepitant to prevent chemotherapy-induced nausea and vomiting - open for inclusion

Dynamic FDG-PET  Clinical study to evaluate the use of dynamic FDG-PET scan in pediatric oncology - open for inclusion

FOCUS (all cancer types)  Clinical study to optimize dosing of fluconazole in children for the prevention or treatment of invasive fungal infections - open for inclusion

FOLLOW-ON study (ALL)  Clinical study investigating the long-term outcome of childhood acute lymphoblastic leukemia (ALL) survivors who have experienced symptomatic osteonecrosis during or shortly after discontinuation of treatment - open for inclusion

International Leukemia/Lymphoma Target Board (iLTB) for relapsed and refractory leukemia/lymphoma An international platform of experts that aims to make access to drug trials for children with relapsed or refractory leukemia and lymphoma as standardized as possible - open for inclusion

MIMIC AML (acute myeloid leukemia)  Clinical study of the immune system of children and adolescents with blood cancer - open for inclusion

PINOCCHIO (multiple types of cancer)  Clinical study in children on the metabolism, distribution and excretion of chemotherapy in the body, also called pharmacokinetics - open for inclusion

Tumor donation in Childhood Cancer patients  This study is designed to enable post-mortem tumor donation in children who die from all different types of pediatric solid and brain tumors, to enable research on end-stage disease - open for inclusion

VANISH  Clinical study of scans of fungal infections in the lungs -open for inclusion

VIKinG (AML & Burkitt lymphoma)  Clinical study of the gut microbiota as predictor for bloodstream infections in children with cancer - open for inclusion