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Here you will find summaries of a selection of ongoing clinical trials on leukemia.

Trials with medicinal products

ALLTogether1 (ALL)  Clinical study concerning the ALLTogether1 treatment protocol for children and young adults with acute lymphoblastic leukemia (ALL) - open for inclusion

AMoRe2017 (AML)  Clinical study of the safety and efficacy of azacitidine in children and adolescents with a molecular relapse of acute myeloid leukemia (AML) - open for inclusion

Blinatumomab (infant ALL)  Clinical study of the feasibility, safety and efficacy of adding blinatumomab to the standard treatment of infants with MLL-rearranged acute lymphoblastic leukemia (ALL) - closed for inclusion

Bosutinib (CML)  Clinical study of the safety and efficacy of bosutinib in children and teenagers with chronic myeloid leukemia (CML) - open for inclusion

Daratumumab ALL2005 – Delphinus (ALL/LL)  Clinical study of the combination of daratumumab with standard chemotherapy for the treatment of children and young adults with relapsed acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL) - closed for inclusion

ESMART (different tumor types)  Clinical study in children with cancer into the safety and efficacy of drugs matching a specific DNA alteration in the tumor - open for inclusion

Inotuzumab ITCC-059 (ALL/B-cell leukemia/lymphoma)  Clinical study of the safety and efficacy of the drug Inotuzumab Ozogamicin (InO) in children with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL) or other CD22-positive malignancies - open for inclusion

Ponatinib INCB084344 (leukemia/solid tumors)  Clinical study of the safety and efficacy of ponatinib for the treatment of different types of leukemia or solid tumors in children - open for inclusion

Venetoclax M13-833 (hematologic/solid tumors)  Clinical study of the safety and efficacy of the drug venetoclax in children and young adults - open for inclusion

ZUMA-4 (ALL/NHL)  Clinical study of the safety and efficacy of KTE-X19 in pediatric and adolescent subjects with relapsed or refractory B-precursor acute lymphoblastic leukemia (ALL) or relapsed or refractory B-cell non-Hodgkin lymphoma (NHL) - open for inclusion


Other trials

Breath analysis (hemato-oncological disease)  A clinical pilot study of exhaled breath as an approach in the diagnostic work-up for an invasive fungal infection in the lungs of children with an impaired immune system - open for inclusion

PINOCCHIO (multiple types of cancer)  Clinical study in children on the metabolism, distribution and excretion of chemotherapy in the body, also called pharmacokinetics - open for inclusion

VIKinG (AML & Burkitt lymphoma)  Clinical study of the gut microbiota as predictor for bloodstream infections in children with cancer - open for inclusion