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Here you will find summaries of a selection of ongoing clinical trials on lymphoma.

Trials with medicinal products

BIANCA (B-NHL)  Clinical study with tisagenlecleucel in children and adolescents with B-cell non-Hodgkin lymphoma (B-NHL) - closed for inclusion

CRISP (tumors with ALK/MET/ROS1 abnormalities)  Clinical study of the safety and efficacy of the drug crizotinib in children, either alone or in combination with other drugs - open for inclusion

Daratumumab ALL2005 – Delphinus ( ALL/LL) Clinical study of the combination of daratumumab with standard chemotherapy for the treatment of children and young adults with relapsed acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL) - open for inclusion

Durvalumab D419EC00001 (hematological/solid tumors)  Clinical study to evaluate the safety, tolerability and efficacy of durvalumab, or durvalumab in combination with tremelimumab, in young patients with advanced solid tumors or hematological malignancies - open for inclusion

ESMART (different tumor types)  Clinical study in children with cancer into the safety and efficacy of drugs matching a specific DNA alteration in the tumor - open for inclusion

Inotuzumab ITCC-059 (ALL/B-cell leukemia/lymphoma) Clinical study of the safety and efficacy of the drug Inotuzumab Ozogamicin (InO) in children with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL) or other CD22-positive malignancies - open for inclusion

Nivolumab CA 209-744 (Hodgkin-lymphoma)  Clinical study of the safety, tolerability and efficacy of the drug nivolumab in combination with brentuximab vedotin in children with classic Hodgkin lymphoma - closed for inclusion

Ponatinib INCB084344 (leukemia/solid tumors)  Clinical study of the safety and efficacy of ponatinib for the treatment of different types of leukemia or solid tumors in children - open for inclusion

Venetoclax M13-833 (hematologic/solid tumors) Clinical study of the safety and efficacy of the drug venetoclax in children and young adults - open for inclusion

Other trials

Breath analysis (hemato-oncological disease)A clinical pilot study of exhaled breath as an approach in the diagnostic work-up for an invasive fungal infection in the lungs of children with an impaired immune system - open for inclusion

NHL-IgA study (B-NHL)  Clinical study of the activity of IgA therapy (antibody therapy) in the laboratory, using blood from children and teenagers with B-cell non-Hodgkin lymphoma (B-NHL) - open for inclusion

PINOCCHIO (multiple types of cancer)Clinical study in children on the metabolism, distribution and excretion of chemotherapy in the body, also called pharmacokinetics - open for inclusion

VIKinG (AML & Burkitt lymphoma)  Clinical study of the gut microbiota as predictor for bloodstream infections in children with cancer - open for inclusion