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Stem cell transplantation and gene therapy

Here you will find summaries of a selection of ongoing clinical trials on stem cell transplantation and gene therapy.

ALD-104 (CALD)  Clinical study of the Lenti-D drug product (gene therapy) in boys with cerebral adrenoleukodystrophy - temporarily closed for inclusion

MetVasA (SCT survivors)  Clinical study of specific late effects of hematopoietic stem cell transplantation in childhood - open for inclusion

Long-term HIT (Stem cell transplantation)  Clinical study investigating blood production in stem cell transplantation survivors - open for inclusion

OMS721-HCT-002 narsoplimab (high-risk HSCT-TMA)  Clinical study of narsoplimab in children with thrombotic microangiopathy following allogeneic hematopoietic stem cell transplantation - open for inclusion

OTL-203-02 / HURCULES (MPS-IH)  Clinical study of a new gene therapy (OTL-203) compared to a standard treatment as a safe and effective alternative to treat mucopolysaccharidosis Type I, Hurler syndrome (MPS-IH) - open for inclusion

PIKACHU (Stem cell transplantation)  Clinical study of precision dosing of prednisolone as either prophylaxis or treatment of graft-versus-host disease after hematopoetic stem cell transplantation - open for inclusion

SCRIPT-AML (Stem cell transplantation in Acute Myeloid Leukemia)  Clinical study of conditioning regimen in stem cell transplantation - open for inclusion

VANISH  Clinical study of scans of fungal infections in the lungs - open for inclusion