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Annelienke van Hulst

Former MD PhD student
Annelienke van Hulst
Annelienke van Hulst
DexaDagen-2 study: Randomized trial on the effect of hydrocortison on behavioral side effects in children with acute lymphatic leukemia (ALL).
Phone +31 (0) 6 25 71 04 85

Dexamethasone, a highly effective drug in treating pediatric acute lymphoblastic leukemia (ALL), can induce serious neurobehavioral side effects, which are experienced as most detrimental with respect to quality of life by patients and parents. Based on previous studies it has been suggested that these side effects are caused by cortisol depletion of the mineralocorticoid receptor in the brain. Our recently reported randomized controlled trial, the DexaDagen-1 study, showed that clinically relevant neurobehavioral problems decrease by hydrocortisone addition during dexamethasone treatment. Validation of these results is required in a selected larger sample before further implementing this treatment into clinical practice.

Annelienke is supervised by Prof. Dr. M.M. van den Heuvel-Eibrink, Prof. Dr. M.A. Grootenhuis and Dr. E.L.T. van den Akker (Erasmus MC).
  • The role of the mineralocorticoid receptor in steroid-induced cytotoxicity in pediatric acute lymphoblastic leukemia

    • jan. 2024
    • Annelienke M, Van Hulst, et al
    • Haematologica
  • Leptin increase during dexamethasone and its association with hunger and fat, in pediatric acute lymphoblastic leukemia

    • jan. 2023
    • Annelienke M, van Hulst, et al
    • The Journal of clinical endocrinology and metabolism
  • The utility of a portable muscle ultrasound in the assessment of muscle alterations in children with acute lymphoblastic leukaemia

    • jan. 2023
    • Emma J, Verwaaijen, et al
    • Journal of cachexia, sarcopenia and muscle
  • Physical frailty deteriorates after a 5-day dexamethasone course in children with acute lymphoblastic leukemia, results of a national prospective study

    • jan. 2023
    • Emma J, Verwaaijen, et al
    • Cancer Medicine
  • Response to letter entitled

    • jan. 2023
    • Annelienke M, van Hulst, et al
    • European journal of cancer (Oxford, England : 1990)
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