PI: Dr. Marita Partanen
Screening of neuropsychological impairments
Cognitive skills may be impacted after treatment for cancer. A change in overall IQ or related domains may impact a child’s quality of life during and after treatment. These cognitive deficits may be caused by various factors, but it is possible to detect these deficits early in treatment or survivorship. One aim of our research is to identify neuropsychological impairments in patients with cancer using a longitudinal screening battery.
Neurobiological bases of neuropsychological impairments
Declines in cognitive performance have been associated with white matter impairments in the brain. Other subtle changes can be detected with neuroimaging, which can provide further insight into the neurobiological substrates of and interventions for cognitive deficits in pediatric oncology. One aim of our research is to determine whether vascular, structural, or functional changes in the brain are associated with neurocognitive functioning in patients with cancer
- Partanen M, Kang G, Wang WC, Krull K, King AA, Schreiber JE, Porter JS, Hodges J, Hankins JS, Jacola LM (in press). Association between hydroxycarbamide exposure and neurocognitive function in adolescents with sickle cell disease. British Journal of Haemtaology.
- Partanen M, Bouffet E, Laughlin S, Strother D, Hukin J, Skocic J, Szulc-Lerch K, Mabbott DJ. (2018). Early changes in white matter predict intellectual outcome in children treated for posterior fossa tumors. NeuroImage Clinical, 20, 697-704. https://doi.org/10.1016/j.nicl.2018.09.005
- Partanen M, Siegel LS, Giaschi D. (2019). Effect of reading intervention and task difficulty on orthographic and phonological reading systems in the brain. Neuropsychologia, 130, 13-25. https://doi.org/10.1016/j.neuropsychologia.2018.07.018
- Partanen M, Siegel LS, Giaschi D. (2019). Longitudinal outcomes of an individualized and intensive reading intervention for third grade students. Dyslexia, 25, 227-245. https://doi.org/10.1002/dys.1616
- Partanen M, Siegel LS (2014). Long-term outcome of the early identification and intervention of reading disabilities. Reading and Writing: An Interdisciplinary Journal, 27, 665-684. https://doi.org/10.1007/s11145-013-9472-1