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Soft tissue tumor (sarcoma)

Here you will find summaries of selected ongoing clinical trials on soft tissue tumors (sarcomas).

Trials with medicinal products

BrigaPED (tumors with ALK defect)  Clinical study into the safety and effectiveness of brigatinib in children and young adults with ALK+ ALCL, IMT and other solid tumors with abnormalities in the ALK gene - open for inclusion

CRISP (tumors with ALK/MET/ROS1 abnormalities)  Clinical study of the safety and efficacy of the drug crizotinib in children, either alone or in combination with other drugs - open for inclusion

ESMART (different tumor types)  Clinical study in children with cancer into the safety and efficacy of drugs matching a specific DNA alteration in the tumor - open for inclusion

INFORM2 NivEnt (various solid tumors) Clinical study with nivolumab and entinostat in children and young adults with refractory cancer - open for inclusion

LOXO-TRK-15003 (solid/CNS tumors)  Clinical study of the safety and efficacy of the drug LOXO-101 (larotrectinib) in children with advanced solid tumors or primary central nervous system tumors - closed for inclusion

Ponatinib INCB084344 (leukemia/solid tumors)  Clinical study of the safety and efficacy of ponatinib for the treatment of different types of leukemia or solid tumors in children - open for inclusion


Other trials

DRUG Access protocol (solid tumors)  A national protocol to facilitate access to new anti-cancer drugs and collect data from targeted anti-cancer drugs not yet eligible for reimbursement - open for inclusion

FOCUS  Clinical study to optimize dosing of fluconazole in children for the prevention or treatment of invasive fungal infections - open for inclusion

PINOCCHIO (multiple types of cancer)  Clinical study in children on the metabolism, distribution and excretion of chemotherapy in the body, also called pharmacokinetics - open for inclusion

Tumor donation in Childhood Cancer patients  This study is designed to enable post-mortem tumor donation in children that die from all different types of pediatric solid and brain tumors, to enable research on end-stage disease - open for inclusion