Survivors of childhood cancer are at increased risk of late morbidities, including the development of subsequent tumors. More knowledge on risks of and risk factors for subsequent tumors is essential to predict which survivors are at highest and at lowest risk. This is important to guide follow-up recommendations and the development of new treatment protocols of children with cancer. As an epidemiologist, I coordinate various projects on subsequent tumors in childhood cancer survivors, which address clinically-relevant questions and gaps in knowledge. Currently, I am supervising several PhD students and research assistants on different projects:
- Colorectal adenoma and cancer risk after treatment for pediatric cancers
- Risk factors for female breast cancer after treatment for childhood cancer in an internationally pooled cohort (more information: PhD Project Yuehan Wang)
- Risk and time trends of subsequent tumors after five decades of pediatric cancer treatment (more information: PhD Project Aimée Westerveld)
- Radiotherapy-related meningioma, cerebrovascular events, and cataract in childhood cancer survivors (more information: PhD Project Lisanne Verbruggen and research assistant Jikke Wams)
- Health problems after 3D-planned pediatric radiotherapy: A nation-wide cohort study (more information: PhD Project Josien Hazewinkel-Beijer and research assistant Aslihan Mantici)
Supervisor(s): Leontien Kremer
Key Publications:
Teepen JC, van Leeuwen FE, Tissing WJ, van Dulmen-den Broeder E, van den Heuvel-Eibrink MM, van der Pal HJ, Loonen JJ, Bresters D, Versluys B, Neggers SJCMM, Jaspers MWM, Hauptmann M, van der Heiden-van der Loo M, Visser O, Kremer LCM, Ronckers CM; DCOG LATER Study Group. Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy. J Clin Oncol. 2017 Jul 10; 35(20):2288-2298. doi: 10.1200/JCO.2016.71.6902. Epub 2017 May 22. PubMed PMID: 28530852.
Teepen JC, Kok JL, van Leeuwen FE, Tissing WJE, Dolsma WV, van der Pal HJ, Loonen JJ, Bresters D, Versluys B, van den Heuvel-Eibrink MM, van Dulmen-den Broeder E, van den Berg MH, van der Heiden-van der Loo M, Hauptmann M, Jongmans MC, Overbeek LI, van de Vijver MJ, Kremer LCM, Ronckers CM; DCOGLATER Study Group. Colorectal Adenomas and Cancers After Childhood Cancer Treatment: A DCOG-LATER Record Linkage Study. J Natl Cancer Inst. 2018 Jul 1; 110(7):758-767. doi: 10.1093/jnci/djx266. PubMed PMID: 29986097.
Teepen JC, Kok JL, Kremer LC, Tissing WJE, van den Heuvel-Eibrink MM, Loonen JJ, Bresters D, van der Pal HJ, Versluys B, van Dulmen-den Broeder E, Nijsten T, Hauptmann M, Hollema N, Dolsma WV, van Leeuwen FE, Ronckers CM; DCOG-LATER Study Group. Long-Term Risk of Skin Cancer Among Childhood Cancer Survivors: A DCOG-LATER Cohort Study. J Natl Cancer Inst. 2019 Feb 25. doi: 10.1093/jnci/djy212. [Epub ahead of print] PubMed PMID: 30802904; PubMed Central PMCID: PMC6695299.
Teepen JC, Kremer LC, van der Heiden-van der Loo M, Tissing WJ, van der Pal HJ, van den Heuvel-Eibrink MM, Loonen JJ, Louwerens M, Versluys B, van Dulmen-den Broeder E, Visser O, Maduro JH, van Leeuwen FE, Ronckers CM; DCOG-LATER Study Group. Clinical characteristics and survival patterns of subsequent sarcoma, breast cancer, and melanoma after childhood cancer in the DCOG-LATER cohort. Cancer Causes Control. 2019 Sep;30(9):909-922. doi: 10.1007/s10552-019-01204-z. Epub 2019 Jul 12. PubMed PMID: 31300947.