Trials with medicinal products
CabOSTar CLIN-60000-461 (osteosarcoma) Clinical study of the effects of maintenance cabozantinib + best supportive care (BSC) versus BSC in children, adolescents and young adults with osteosarcoma - open for inclusion
CRISP (tumors with ALK/MET/ROS1 abnormalities) Clinical study of the safety and efficacy of the drug crizotinib in children, either alone or in combination with other drugs - open for inclusion
ESMART (different tumor types) Clinical study in children with cancer into the safety and efficacy of drugs matching a specific DNA alteration in the tumor - open for inclusion
INFORM2 NivEnt (various solid tumors) Clinical study with nivolumab and entinostat in children and young adults with refractory cancer - open for inclusion
LOXO-TRK-15003 (solid/CNS tumors) Clinical study of the safety and efficacy of the drug LOXO-101 (larotrectinib) in children with advanced solid tumors or primary central nervous system tumors - closed for inclusion
MK-3475-051 pembrolizumab (melanoma, solid tumor, lymphoma) Clinical study with the study drug MK-3475 in children with skin cancer (melanoma), solid tumor or lymphoma - open for inclusion
MK9999-01A (Bone tumors) Clinical study into zilovertamab vedotin for the treatment of children with hematological malignancies or solid tumors. In the Netherlands the study is only open for children or adolescents with bone tumors - open for inclusion
Ponatinib INCB084344 (leukemia/solid tumors) Clinical study of the safety and efficacy of ponatinib for the treatment of different types of leukemia or solid tumors in children - open for inclusion
REGO-INTER-EWING-1 (Ewing sarcoma) Clinical study on the treatment of children and young adults with metastatic Ewing sarcoma - open for inclusion
Other trials
DAVINCY (all cancer types) Clinical study of extended use of the drug (fos)aprepitant to prevent chemotherapy-induced nausea and vomiting - open for inclusion
DRUG Access protocol (solid tumors) A national protocol to facilitate access to new anti-cancer drugs and collect data from targeted anti-cancer drugs not yet eligible for reimbursement - open for inclusion
Dynamic FDG-PET Clinical study to evaluate the use of dynamic FDG-PET scan in pediatric oncology - open for inclusion
Fluorescence with ICG in Sarcoma Surgery (Tumors of Bones and Soft Tissues) Clinical study of the presence of indocyanine green (ICG) fluorescence in vital and dead tumor cells - open for inclusion
FOCUS (all cancer types) Clinical study to optimize dosing of fluconazole in children for the prevention or treatment of invasive fungal infections - open for inclusion
Follow-up clinic bone sarcomas (Osteosarcoma & Ewing sarcoma) Clinical study of long term functioning after surgery or radiation therapy for a pediatric bone sarcoma - open for inclusion
PINOCCHIO (multiple types of cancer) Clinical study in children on the metabolism, distribution and excretion of chemotherapy in the body, also called pharmacokinetics - open for inclusion
Tumor donation in Childhood Cancer patients This study is designed to enable post-mortem tumor donation in children that die from all different types of pediatric solid and brain tumors, to enable research on end-stage disease -open for inclusion